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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F05%3A00027661%21RIV06-AV0-68378050
rdf:type
n5:Vysledek skos:Concept
dcterms:description
In order to elucidate the mechanisms involved in apoptosis induction by iron deprivation, we compared cells sensitive (38C13) and resistant (EL4) to apoptosis induced by iron deprivation. Iron deprivation was achieved by incubation in a defined iron-free medium. We detected the activation of caspase-3 and caspase-9 only in sensitive cells under iron deprivation. Iron deprivation led to the release of cytochrome c from mitochondria into the cytosol only in sensitive cells. The mitochondrial membrane potential (MMP) was dissipated within 24 h in sensitive cells due to iron deprivation. The antiapoptotic Bcl-2 protein was found to be associated with mitochondria in both sensitive and resistant cells and the association did not change under iron deprivation. However, under iron deprivation we detected translocation of the proapoptotic Bax protein from the cytosol to mitochondria only in sensitive cells. Abychom objasnili mechanismus uplatněný v indukci apoptózy deprivací železa, srovnávali jsme buňky sensitivní (38C13) a resistentní (EL4) k buněčné smrti indukované deprivací železa. Deprivaci železa jsme navodili kultivaci buněk v bezželezém médiu. V podmínkách deprivace železa jsme u sensitivních buněk detekovali aktivaci kaspázy 3 a kaspázy 9. Deprivace železa u sensitivních buněk dále vedla k uvolnění cytochromu c z mitochondrií do cytosolu. V důsledku deprivace železa došlo u sensitivních buněk k zhroucení mitochondriálního membránového potenciálu (MMP) během 24 h. Antiapoptotický protein Bax byl nalezen na mitochondriích jak u sensitivních tak i resistentních buněk a tato asociace s mitochondriemi se vlivem deprivace železa nezměnila. Avšak za podmínek deprivace železa jsme detekovali translokaci apoptotického Bax proteinu z cytosolu na mitochondrie u sensitivních buněk k indukci apoptózy. In order to elucidate the mechanisms involved in apoptosis induction by iron deprivation, we compared cells sensitive (38C13) and resistant (EL4) to apoptosis induced by iron deprivation. Iron deprivation was achieved by incubation in a defined iron-free medium. We detected the activation of caspase-3 and caspase-9 only in sensitive cells under iron deprivation. Iron deprivation led to the release of cytochrome c from mitochondria into the cytosol only in sensitive cells. The mitochondrial membrane potential (MMP) was dissipated within 24 h in sensitive cells due to iron deprivation. The antiapoptotic Bcl-2 protein was found to be associated with mitochondria in both sensitive and resistant cells and the association did not change under iron deprivation. However, under iron deprivation we detected translocation of the proapoptotic Bax protein from the cytosol to mitochondria only in sensitive cells.
dcterms:title
Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation Deprivace železa indukuje apoptózu skrze mitochondriální změny související s Bax translokací Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation
skos:prefLabel
Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation Deprivace železa indukuje apoptózu skrze mitochondriální změny související s Bax translokací Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation
skos:notation
RIV/68378050:_____/05:00027661!RIV06-AV0-68378050
n3:strany
381;393
n3:aktivita
n12:P n12:Z
n3:aktivity
P(GA301/01/0041), Z(AV0Z5052915)
n3:cisloPeriodika
2
n3:dodaniDat
n13:2006
n3:domaciTvurceVysledku
n8:7020597 n8:9013431 n8:1758330 n8:7577117 n8:6608035
n3:druhVysledku
n15:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
525687
n3:idVysledku
RIV/68378050:_____/05:00027661
n3:jazykVysledku
n7:eng
n3:klicovaSlova
apoptosis; iron deprivation; mitochondrial apoptotic pathway
n3:klicoveSlovo
n4:mitochondrial%20apoptotic%20pathway n4:apoptosis n4:iron%20deprivation
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[381BF3C45E13]
n3:nazevZdroje
Apoptosis
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n16:GA301%2F01%2F0041
n3:rokUplatneniVysledku
n13:2005
n3:svazekPeriodika
10
n3:tvurceVysledku
Naďová, Zuzana Truksa, Jaroslav Ehrlichová, Marie Kovář, Jan Koc, Michal
n3:zamer
n11:AV0Z5052915
s:issn
1360-8185
s:numberOfPages
13