This HTML5 document contains 53 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n8http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n6http://linked.opendata.cz/resource/domain/vavai/projekt/
n14http://linked.opendata.cz/ontology/domain/vavai/
n7http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F68378050%3A_____%2F05%3A00027660%21RIV06-AV0-68378050/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n12http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n15http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F05%3A00027660%21RIV06-AV0-68378050
rdf:type
skos:Concept n14:Vysledek
dcterms:description
This study compared cytotoxicity and transport of paclitaxel and docetaxel with novel taxanes in human breast cancer cells. The cell lines examined differ expression of ABC membrane transporters. Reverse transcription-polymerase chain reaction revealed that NCI/ADR-RES cells expressed high levels of P-glycoprotein mRNA, which was absent in MDA-MB-435 cells, while the opposite was true for MRP2 mRNA. NCI/ADR-RES cells were more resistant to paclitaxel and to docetaxel than MDA-MB-435 cells, but almost equally sensitive to novel taxanes. This complied with the fact that NCI/ADR-RES cells absorbed almost 20-fold less [14C]paclitaxel, about 7-fold less docetaxel, and almost equal amounts of SB-T-1103, SB-T-1214, and SB-T-1216 as the MDA-MB-435 cells. SB-T-1103 and SB-T-1216 did not influence transport of paclitaxel, but SB-T-1214 decreased [14C]paclitaxel uptake in both cell lines indicating inhibition of uptake. This suggests that the novel taxanes are not inhibitors of P-glycoprotein. This study compared cytotoxicity and transport of paclitaxel and docetaxel with novel taxanes in human breast cancer cells. The cell lines examined differ expression of ABC membrane transporters. Reverse transcription-polymerase chain reaction revealed that NCI/ADR-RES cells expressed high levels of P-glycoprotein mRNA, which was absent in MDA-MB-435 cells, while the opposite was true for MRP2 mRNA. NCI/ADR-RES cells were more resistant to paclitaxel and to docetaxel than MDA-MB-435 cells, but almost equally sensitive to novel taxanes. This complied with the fact that NCI/ADR-RES cells absorbed almost 20-fold less [14C]paclitaxel, about 7-fold less docetaxel, and almost equal amounts of SB-T-1103, SB-T-1214, and SB-T-1216 as the MDA-MB-435 cells. SB-T-1103 and SB-T-1216 did not influence transport of paclitaxel, but SB-T-1214 decreased [14C]paclitaxel uptake in both cell lines indicating inhibition of uptake. This suggests that the novel taxanes are not inhibitors of P-glycoprotein. Tato studie srovnávává cytotoxicitu a transport paclitaxel a docetaxelu s novými taxany u lidských buněk nádorů prsu. Tyto zkoumané buněčné linie se liší v expresi membránových ABC transportérů. Na základě reverzní transkripční polymerázy bylo odhaleno, že buňky NCI/ADR-RES exprimují vyšší hladinu P glycoproteinu na úrovni mRNA, který chybí u buněk MDA-MB-435, u nich byla zvýšená hladina MRP2. Buňky NCI/ADR/RES jsou hodně rezistentnější vúči paclitaxelu a docetaxelu než buňky MDA-MB-435, ale obě linie podobně senzitivní vúči novým taxanům. Buňky NCI/ADR-RES absorbují přibližně 20krát méně [14C]paclitaxelu, 7 krát méně docetaxelu a přibližně stejně nových taxanů jako buňky MDA-MB-435. SB-T-1103 a SB-T-1216 neovlivňují transport paclitaxelu, ale SB-T-1214 snižuje uptake u obou buňěčných linií. To vede k závěru, že nové taxany nejsou inhibitory P glykoproteinu.
dcterms:title
Transport a cytotoxicita paclitaxelu, docetaxelu a nových taxanů u lidských buněk nádorů prsu Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells
skos:prefLabel
Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells Transport a cytotoxicita paclitaxelu, docetaxelu a nových taxanů u lidských buněk nádorů prsu Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells
skos:notation
RIV/68378050:_____/05:00027660!RIV06-AV0-68378050
n3:strany
95;105
n3:aktivita
n5:Z n5:P
n3:aktivity
P(GA305/04/0403), P(NL7567), Z(AV0Z50520514)
n3:cisloPeriodika
1
n3:dodaniDat
n15:2006
n3:domaciTvurceVysledku
n8:6608035 n8:7020597 n8:1758330
n3:druhVysledku
n11:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
547137
n3:idVysledku
RIV/68378050:_____/05:00027660
n3:jazykVysledku
n12:eng
n3:klicovaSlova
taxanes; uptake; ABC transporters
n3:klicoveSlovo
n4:taxanes n4:uptake n4:ABC%20transporters
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[737D262FC7FD]
n3:nazevZdroje
Naunyn-Schmiedeberg's Archiv of Pharmacology
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
9
n3:projekt
n6:NL7567 n6:GA305%2F04%2F0403
n3:rokUplatneniVysledku
n15:2005
n3:svazekPeriodika
372
n3:tvurceVysledku
Ojima, I. Kuznetsova, L. V. Václavíková, R. Truksa, Jaroslav Kovář, Jan Pepe, A. Gut, I. Chen, J. Ehrlichová, Marie
n3:zamer
n7:AV0Z50520514
s:issn
0028-1298
s:numberOfPages
11