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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F05%3A00025577%21RIV06-AV0-68378050
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Production of nitric oxide (NO) by graft infiltrating macrophages has been suggested as an important effector mechanism of allograft rejection. Whether NO plays a role in rejection of skin xenografts has not been documented. Here we described a suppressive molecule of molecular mass of 67 kDa which is produced by rejected rat skin xenografts and which selectively inhibits the iNOS activity in graft infiltrating macrophages. Therefore, NO does not play a significant role in rejection of rat skin xenografts as it does in the case of allograft rejection. Produkce oxidu dusnatého (NO) makrofágy infiltrujícími transplantát je považována za důležitý efektorový mechanismus při rejekci alotransplantátů. Zda tento mechanismus hraje roli při rejekci xenotransplantátů není dosud známo. V této práci jsme popsali supresivní molekulu o hmotnosti 67 kDa, která je produkována rejekovaným xenotransplantátem krysí kůže. Tato molekula selektivně inhibuje aktivitu iNOS v makrofázích infiltrovaných v transplantátu. V tomto případě nemůže NO hrát důležitou roli při rejekci xenotranspalntátu krysí kůže, tak jak je tomu v případě alogenní rejekce. Production of nitric oxide (NO) by graft infiltrating macrophages has been suggested as an important effector mechanism of allograft rejection. Whether NO plays a role in rejection of skin xenografts has not been documented. Here we described a suppressive molecule of molecular mass of 67 kDa which is produced by rejected rat skin xenografts and which selectively inhibits the iNOS activity in graft infiltrating macrophages. Therefore, NO does not play a significant role in rejection of rat skin xenografts as it does in the case of allograft rejection.
dcterms:title
The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells Aktivita indukovatelné NO synthasy v rejekovaných kožních xenotransplantátech je selektivně inhibována faktorem produkovaným transplantovanými buňkami The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells
skos:prefLabel
The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells Aktivita indukovatelné NO synthasy v rejekovaných kožních xenotransplantátech je selektivně inhibována faktorem produkovaným transplantovanými buňkami The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells
skos:notation
RIV/68378050:_____/05:00025577!RIV06-AV0-68378050
n5:strany
227;234
n5:aktivita
n15:P n15:Z
n5:aktivity
P(GD310/03/H147), P(GP310/02/D162), P(KSK5020115), P(ME 300), P(NR7816), Z(AV0Z50110509), Z(AV0Z5052915)
n5:cisloPeriodika
3
n5:dodaniDat
n14:2006
n5:domaciTvurceVysledku
n8:9565612 n8:8788839 n8:3674053 n8:5695678 n8:6947891
n5:druhVysledku
n17:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n6:predkladatel
n5:idSjednocenehoVysledku
511318
n5:idVysledku
RIV/68378050:_____/05:00025577
n5:jazykVysledku
n13:eng
n5:klicovaSlova
inducible nitric oxide synthase production; nitric oxide; suppressive molecule
n5:klicoveSlovo
n7:inducible%20nitric%20oxide%20synthase%20production n7:suppressive%20molecule n7:nitric%20oxide
n5:kodStatuVydavatele
DK - Dánské království
n5:kontrolniKodProRIV
[C324060D38C7]
n5:nazevZdroje
Xenotransplantation
n5:obor
n16:EB
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
7
n5:projekt
n9:NR7816 n9:GP310%2F02%2FD162 n9:GD310%2F03%2FH147 n9:KSK5020115 n9:ME%20300
n5:rokUplatneniVysledku
n14:2005
n5:svazekPeriodika
12
n5:tvurceVysledku
Krulová, Magdalena Pindjáková, Jana Zajícová, Alena Svoboda, Petr Železná, Blanka Holáň, Vladimír Matoušek, Petr
n5:zamer
n12:AV0Z5052915 n12:AV0Z50110509
s:issn
0908-665X
s:numberOfPages
8