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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F05%3A00025555%21RIV06-AV0-68378050
rdf:type
n16:Vysledek skos:Concept
dcterms:description
It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function. Předpokládá se, že prozánětlivá odpověď a hyperaktivita HPA osy je zahrnuta v patogenesi deprese. Již dříve jsme zjistili, že antidepresiva inhibují v in vitro podmínkách funkci glukokortikoidního receptoru (GR). Zkoumali jsme vliv LPS na imipramin- nebo fluoxetinem indukovanou inhibici GR ovlivněné genové transkripce ve fibroblastech. Výsledky naznačují, že prozánětlivá agens usnadňují antidepresivy indukovanou inhibici funkce GR. It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function.
dcterms:title
Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription
skos:prefLabel
Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem
skos:notation
RIV/68378050:_____/05:00025555!RIV06-AV0-68378050
n3:strany
540;544
n3:aktivita
n7:Z
n3:aktivity
Z(AV0Z5052915)
n3:cisloPeriodika
4
n3:dodaniDat
n12:2006
n3:domaciTvurceVysledku
n4:6947891 n4:5695678
n3:druhVysledku
n13:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
519348
n3:idVysledku
RIV/68378050:_____/05:00025555
n3:jazykVysledku
n17:eng
n3:klicovaSlova
glucocorticoid receptor; antidepressant drugs; interleukin-6
n3:klicoveSlovo
n15:antidepressant%20drugs n15:interleukin-6 n15:glucocorticoid%20receptor
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[D8979205554A]
n3:nazevZdroje
Pharmacological Reports
n3:obor
n6:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n12:2005
n3:svazekPeriodika
57
n3:tvurceVysledku
Kubera, M. Basta-Kaim, A. Zajícová, Alena Budziszewska, B. Jaworska, L. Leskiewicz, M. Otczyk, M. Tetich, M. Holáň, Vladimír Lasoń, W.
n3:zamer
n8:AV0Z5052915
s:issn
1734-1140
s:numberOfPages
5