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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F05%3A00022522%21RIV06-AV0-68378050
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Oči zvířat se liší z anatomického hlediska. Proto se předpokládalo, že vznikly nezávisle několikrát v průběhu evoluce. Objev genu Pax6 zhruba před deseti lety ale všechny tyto argumenty zpochybnil. Od té doby se objevilo více důkazů pro opakované použití genu Pax6 a některých dalších regulátorů používaných pro genetický program vývoje oka. Nedávný výzkum ukázal, že i některé další geny rodiny Pax hrají klíčovou roli v morfogenezi oka. Animal eyes with widely different anatomical designs have long been thought to arise independently, multiple times during evolution. This view was challenged about a decade ago by the landmark discoveries that Pax6, a highly conserved transcription factor, plays a key role in eye morphogenesis in both flies and mammals. Since then, more evidence has emerged in favour of the redeployment of Pax6 and some other developmental control genes within the genetic program underlying eye formation throughout the animal kingdom. Recent work has indicated that other members of the Pax gene family play a pivotal role in eye morphogenesis. The Eye gone gene regulates eye growth in Drosophila, whereas the PaxB gene is implicated in visual system development in jellyfish, the most basal organism possessing eyes. Animal eyes with widely different anatomical designs have long been thought to arise independently, multiple times during evolution. This view was challenged about a decade ago by the landmark discoveries that Pax6, a highly conserved transcription factor, plays a key role in eye morphogenesis in both flies and mammals. Since then, more evidence has emerged in favour of the redeployment of Pax6 and some other developmental control genes within the genetic program underlying eye formation throughout the animal kingdom. Recent work has indicated that other members of the Pax gene family play a pivotal role in eye morphogenesis. The Eye gone gene regulates eye growth in Drosophila, whereas the PaxB gene is implicated in visual system development in jellyfish, the most basal organism possessing eyes.
dcterms:title
Pax genes in eye development and evolution Geny Pax ve vývoji oka a v evoluci Pax genes in eye development and evolution
skos:prefLabel
Pax genes in eye development and evolution Geny Pax ve vývoji oka a v evoluci Pax genes in eye development and evolution
skos:notation
RIV/68378050:_____/05:00022522!RIV06-AV0-68378050
n3:strany
430;438
n3:aktivita
n17:Z n17:P
n3:aktivity
P(1M0520), P(GA204/04/1358), Z(AV0Z5052915)
n3:cisloPeriodika
4
n3:dodaniDat
n11:2006
n3:domaciTvurceVysledku
n16:6641946
n3:druhVysledku
n8:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
535568
n3:idVysledku
RIV/68378050:_____/05:00022522
n3:jazykVysledku
n4:eng
n3:klicovaSlova
paxpax; eye development; evolution
n3:klicoveSlovo
n12:evolution n12:paxpax n12:eye%20development
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[6559329D7566]
n3:nazevZdroje
Current Opinion in Genetics & Development
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n5:GA204%2F04%2F1358 n5:1M0520
n3:rokUplatneniVysledku
n11:2005
n3:svazekPeriodika
15
n3:tvurceVysledku
Kozmik, Zbyněk
n3:zamer
n14:AV0Z5052915
s:issn
0959-437X
s:numberOfPages
9