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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F05%3A00021377%21RIV06-AV0-68378050
rdf:type
skos:Concept n14:Vysledek
dcterms:description
TGF-b must be activated from the latent form (LTGF-b) to induce biological responses. We report activation of TGF-b by co-operation of the mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) and the u-PAR (CD87). Endothelial cells express CD222 and CD87 in a membrane complex; the association of these two receptors is essential for the release of active TGF-b in the transduced mouse fibroblast. Smooth-muscle cells, which express CD222 and CD87 at similar density to endothelial cells but not in complexed form, do not activate TGF-b. Mini-plasminogen is a high-affinity ligand for CD222 and is essential for the activation of TGF-b by the CD87-CD222 complex to induce apoptosis in endothelial cells. This specific mechanism of TGF-b-mediated apoptosis in endothelial cells is thus a potential novel target for treatment of pathological vascular disorders (e.g. tumor angiogenesis). Tato práce popisuje aktivaci cytokinu TGF-b kooperací receptorů: mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) a u-PAR (CD87). Endotheliální buňky exprimují CD222 a CD87 v membránovém komplexu; asociace těchto receptorů je zásadně důležitá pro uvolnění aktivního TGF-b v transdukovaných myších fibroblastech. Buňky hladkého svalstva, které také exprimují CD222 a CD87, ale v nekomplexní formě, neaktivují TGF-b. Mini-plasminogen je vysokoafinním ligandem CD222 a je zásadně důležitý pro aktivaci TGF-b komplexem CD87-CD222, potřebnou k indukci apoptosy endotheliálních buněk. Tento mechanismus představuje nový potenciální cíl pro léčbu patologických vaskulárních dějů (např. nádorová angiogenesa). TGF-b must be activated from the latent form (LTGF-b) to induce biological responses. We report activation of TGF-b by co-operation of the mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) and the u-PAR (CD87). Endothelial cells express CD222 and CD87 in a membrane complex; the association of these two receptors is essential for the release of active TGF-b in the transduced mouse fibroblast. Smooth-muscle cells, which express CD222 and CD87 at similar density to endothelial cells but not in complexed form, do not activate TGF-b. Mini-plasminogen is a high-affinity ligand for CD222 and is essential for the activation of TGF-b by the CD87-CD222 complex to induce apoptosis in endothelial cells. This specific mechanism of TGF-b-mediated apoptosis in endothelial cells is thus a potential novel target for treatment of pathological vascular disorders (e.g. tumor angiogenesis).
dcterms:title
Apoptóza vyvolaná v endoteliálních buňkách TGF-beta zprostředkovaná M6P/IGFII-R a mini-plasminogenem TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen
skos:prefLabel
Apoptóza vyvolaná v endoteliálních buňkách TGF-beta zprostředkovaná M6P/IGFII-R a mini-plasminogenem TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen
skos:notation
RIV/68378050:_____/05:00021377!RIV06-AV0-68378050
n3:strany
4577;4586
n3:aktivita
n9:Z
n3:aktivity
Z(AV0Z5052915)
n3:cisloPeriodika
19
n3:dodaniDat
n16:2006
n3:domaciTvurceVysledku
n11:7776535
n3:druhVysledku
n15:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
546578
n3:idVysledku
RIV/68378050:_____/05:00021377
n3:jazykVysledku
n13:eng
n3:klicovaSlova
apoptosis; TGF-beta; mini-plasminogen
n3:klicoveSlovo
n4:mini-plasminogen n4:apoptosis n4:TGF-beta
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[296AC87BADB0]
n3:nazevZdroje
Journal of Cell Science
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n16:2005
n3:svazekPeriodika
118
n3:tvurceVysledku
Hořejší, Václav Slezakova, K. Godar, S. Schiller, H. B. Weidle, U. H. Muhammad, A. Steinlein, P. Leksa, V. Stockinger, H. Fuertbauer, E. Binder, B. R.
n3:zamer
n5:AV0Z5052915
s:issn
0021-9533
s:numberOfPages
10