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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F04%3A23033189%21RIV%2F2004%2FAV0%2FA23004%2FN
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Chemokines play an important role in the recruitment of leukocytes and have recently been shown to also attract regulatory T cells. Using blocking mAbs, we analyzed the role of the chemokine receptor CCR2 during initiation and progression of collagen-induced arthritis in mice. Blockade of CCR2 from days 0 to 15 markedly improved clinical signs of arthritis and histological scores measuring leukocyte infiltration, synovial hyperplasia, and bone and cartilage erosion. CCR2 blockade during disease initiation significantly reduced plasma titers of collagen Abs in vivo. In vitro CCR2 blockade also interfered with collagen-specific activation and proliferation of T cells. Surprisingly, CCR2 blockade from days 21 to 36 markedly aggravated clinical and histological signs of arthritis and increased the Immoral immune response against collagen. We show that CCR2 is expressed on regulatory T cells. Purified CCR2(+) T cells are fully anergic toward polyclonal and collagen-specific activation and potently suppress Chemokines play an important role in the recruitment of leukocytes and have recently been shown to also attract regulatory T cells. Using blocking mAbs, we analyzed the role of the chemokine receptor CCR2 during initiation and progression of collagen-induced arthritis in mice. Blockade of CCR2 from days 0 to 15 markedly improved clinical signs of arthritis and histological scores measuring leukocyte infiltration, synovial hyperplasia, and bone and cartilage erosion. CCR2 blockade during disease initiation significantly reduced plasma titers of collagen Abs in vivo. In vitro CCR2 blockade also interfered with collagen-specific activation and proliferation of T cells. Surprisingly, CCR2 blockade from days 21 to 36 markedly aggravated clinical and histological signs of arthritis and increased the Immoral immune response against collagen. We show that CCR2 is expressed on regulatory T cells. Purified CCR2(+) T cells are fully anergic toward polyclonal and collagen-specific activation and potently suppress
dcterms:title
Dual role of CCR2 during initiation and progression of collagen-induced arthritis: Evidence for regulatory activity of CCR2(+) T cells. Dual role of CCR2 during initiation and progression of collagen-induced arthritis: Evidence for regulatory activity of CCR2(+) T cells.
skos:prefLabel
Dual role of CCR2 during initiation and progression of collagen-induced arthritis: Evidence for regulatory activity of CCR2(+) T cells. Dual role of CCR2 during initiation and progression of collagen-induced arthritis: Evidence for regulatory activity of CCR2(+) T cells.
skos:notation
RIV/68378050:_____/04:23033189!RIV/2004/AV0/A23004/N
n3:strany
890;898
n3:aktivita
n11:Z
n3:aktivity
Z(AV0Z5052915)
n3:cisloPeriodika
172
n3:dodaniDat
n12:2004
n3:domaciTvurceVysledku
n13:1420275
n3:druhVysledku
n14:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
561281
n3:idVysledku
RIV/68378050:_____/04:23033189
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Chemokine receptor 2; monocyte chemoattractant protein; adjuvant-induced arthritis
n3:klicoveSlovo
n7:monocyte%20chemoattractant%20protein n7:adjuvant-induced%20arthritis n7:Chemokine%20receptor%202
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[9BDB6B483560]
n3:nazevZdroje
Journal of immunology
n3:obor
n10:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n12:2004
n3:svazekPeriodika
2004
n3:tvurceVysledku
Milz, J. W. Shakaremi, M. Schlöndorf, D. Wenzel, I. Plachý, Jiří Mack, M. Schneider, M. A. Rupp, T. Stangassinger, M. Brühl, H. Čihák, J.
n3:zamer
n17:AV0Z5052915
s:issn
0022-1767
s:numberOfPages
9