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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F04%3A00105347%21RIV10-AV0-68378050
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Activation of the B cell antigen receptor triggers phosphorylation of cytoplasmic and transmembrane adaptor proteins such as SLP-65 and NTAL, respectively. Specific phosphoacceptor sites in SLP-65 serve as docking sites for Ca(2+)-mobilizing enzymes Btk and PLC-gamma2. Phosphorylated NTAL recruits the Grb2 linker, but downstream signaling cascades are unclear. We now show that receptor-induced tyrosine phosphorylation of NTAL and concomitant Grb2 complex formation critically modulate the Ca(2+) response without affecting SLP-65 and PLC-gamma2 phosphorylation. Grb2 turned out to play a negative regulatory role, which appears to be eliminated upon binding to NTAL. This allows for a sustained release of intracellular Ca(2+) and is mandatory for subsequent entry of Ca(2+) from extracellular sources. Thus, elevation of Ca(2+) is regulated by at least two signaling modules, the B cell-specific Ca(2+) initiation complex comprising SLP-65, Btk, and PLC-gamma2 and the more ubiquitously expressed NTAL/Grb2 c... Activation of the B cell antigen receptor triggers phosphorylation of cytoplasmic and transmembrane adaptor proteins such as SLP-65 and NTAL, respectively. Specific phosphoacceptor sites in SLP-65 serve as docking sites for Ca(2+)-mobilizing enzymes Btk and PLC-gamma2. Phosphorylated NTAL recruits the Grb2 linker, but downstream signaling cascades are unclear. We now show that receptor-induced tyrosine phosphorylation of NTAL and concomitant Grb2 complex formation critically modulate the Ca(2+) response without affecting SLP-65 and PLC-gamma2 phosphorylation. Grb2 turned out to play a negative regulatory role, which appears to be eliminated upon binding to NTAL. This allows for a sustained release of intracellular Ca(2+) and is mandatory for subsequent entry of Ca(2+) from extracellular sources. Thus, elevation of Ca(2+) is regulated by at least two signaling modules, the B cell-specific Ca(2+) initiation complex comprising SLP-65, Btk, and PLC-gamma2 and the more ubiquitously expressed NTAL/Grb2 c...
dcterms:title
Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes
skos:prefLabel
Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes
skos:notation
RIV/68378050:_____/04:00105347!RIV10-AV0-68378050
n3:aktivita
n4:Z n4:P
n3:aktivity
P(LN00A026), Z(AV0Z5052915)
n3:cisloPeriodika
5
n3:dodaniDat
n8:2010
n3:domaciTvurceVysledku
n13:7776535
n3:druhVysledku
n16:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
565767
n3:idVysledku
RIV/68378050:_____/04:00105347
n3:jazykVysledku
n15:eng
n3:klicovaSlova
NTAL; Grb2; lymphocyte
n3:klicoveSlovo
n6:lymphocyte n6:Grb2 n6:NTAL
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[069D5E4043C4]
n3:nazevZdroje
Immunity
n3:obor
n18:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:projekt
n14:LN00A026
n3:rokUplatneniVysledku
n8:2004
n3:svazekPeriodika
21
n3:tvurceVysledku
Stork, B. Frey, J. Schraven, B. Hamm-Baarke, A. Hořejší, Václav Engelke, M. Wienands, J. Kurosaki, T.
n3:zamer
n17:AV0Z5052915
s:issn
1074-7613
s:numberOfPages
10