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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F04%3A00105307%21RIV%2F2005%2FAV0%2FA23005%2FN
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Cells of transplantable MC38 colon carcinoma of C57BL/6 mice were adapted to growth in vitro, preserving their tumorigenicity. After transduction with a retroviral vector carrying murine interleukin 12 genes, stable transductant cells were obtained producing IL-12. After subcutaneous inoculation into syngeneic mice, the IL-12-modified cells showed reduced tumorigenicity as compared to parental cells. The obtained results show that the transduced cells could be used both as a model tumour for the study of anticancer immunity and/or as an adjuvant to cancer vaccines Cells of transplantable MC38 colon carcinoma of C57BL/6 mice were adapted to growth in vitro, preserving their tumorigenicity. After transduction with a retroviral vector carrying murine interleukin 12 genes, stable transductant cells were obtained producing IL-12. After subcutaneous inoculation into syngeneic mice, the IL-12-modified cells showed reduced tumorigenicity as compared to parental cells. The obtained results show that the transduced cells could be used both as a model tumour for the study of anticancer immunity and/or as an adjuvant to cancer vaccines Buňky transplantovatelného karcinomu tlustého střeva MC38 myší C57BL/6 byly adaptovány pro růst in vitro bez ztráty tumorigenicity. Po transdukci retrovirovým vektorem nesoucím geny pro myší IL-12 byly získány stabilní transdukované buňky produkující IL-12. Po subkutánní inokulaci do syngenních myší vykazovaly buňky modifikované IL-12 ve srovnání s parentálními buňkami sníženou tumorigenicitu. Získané výsledky ukazují, že transdukované buňky bude možno využít jako modelový nádor pro studium protinádorové imunity a/nebo jako adjuvans pro nádorové vakcíny
dcterms:title
Ztráta tumorigenicity myší buněčné linie karcinomu tlustého střeva MC38/0 po transdukci retrovirovým vektorem nesoucím geny pro myší IL-12 Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes
skos:prefLabel
Ztráta tumorigenicity myší buněčné linie karcinomu tlustého střeva MC38/0 po transdukci retrovirovým vektorem nesoucím geny pro myší IL-12 Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes
skos:notation
RIV/68378050:_____/04:00105307!RIV/2005/AV0/A23005/N
n3:strany
7;14
n3:aktivita
n10:Z
n3:aktivity
Z(AV0Z5052915)
n3:cisloPeriodika
1
n3:dodaniDat
n8:2005
n3:domaciTvurceVysledku
n13:9414185
n3:druhVysledku
n15:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
571820
n3:idVysledku
RIV/68378050:_____/04:00105307
n3:jazykVysledku
n6:eng
n3:klicovaSlova
MC38 murine colon carcinoma; IL-12 transduction; tumorigenicity
n3:klicoveSlovo
n4:MC38%20murine%20colon%20carcinoma n4:tumorigenicity n4:IL-12%20transduction
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F33EFBB77110]
n3:nazevZdroje
Folia Biologica
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n8:2004
n3:svazekPeriodika
50
n3:tvurceVysledku
Mackiewicz, A. Krawczenko, A. Indrová, Marie DuĽ, D. Grabarczyk, P. Szyda, A. Wysocki, P. Pajtasz-Piasecka, E. Rossowska, J.
n3:zamer
n16:AV0Z5052915
s:issn
0015-5500
s:numberOfPages
8