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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F04%3A00000219%21RIV%2F2005%2FAV0%2FA23005%2FN
rdf:type
skos:Concept n15:Vysledek
dcterms:description
V doménách pro vazbu na DNA a pro oligomerizaci genu TP53 byly detegovány četné delece v pozdních i časných in vitro pasážích kuřecí nádorové buněčné linie PR9692. Tato nádorová buněčná linie vykazuje imortalizovaný fenotyp a získala schopnost metastazovat, která je výjimečná v rámci našeho modelu nádorů vyvolaných v-src u kongenních kuřat. We have detected frequent deletions of variable length in both DNA-binding and oligomerization domains of the TP53 in the late as well as early in vitro passages of the chicken tumor cell line PR9692. This tumor cell line shows an immortal phenotype and acquires a metastatic potential that is unique in our experimental model of v-src-induced tumors in congenic chicken. We have detected frequent deletions of variable length in both DNA-binding and oligomerization domains of the TP53 in the late as well as early in vitro passages of the chicken tumor cell line PR9692. This tumor cell line shows an immortal phenotype and acquires a metastatic potential that is unique in our experimental model of v-src-induced tumors in congenic chicken.
dcterms:title
Delece ve vazebné doméně pro DNA genu TP53 u kuřecích buněk transformovaných v-src Deletions in the DNA-binding domain of the TP53 gene in v-src-transformed chicken cells Deletions in the DNA-binding domain of the TP53 gene in v-src-transformed chicken cells
skos:prefLabel
Delece ve vazebné doméně pro DNA genu TP53 u kuřecích buněk transformovaných v-src Deletions in the DNA-binding domain of the TP53 gene in v-src-transformed chicken cells Deletions in the DNA-binding domain of the TP53 gene in v-src-transformed chicken cells
skos:notation
RIV/68378050:_____/04:00000219!RIV/2005/AV0/A23005/N
n3:strany
285;292
n3:aktivita
n12:P n12:Z
n3:aktivity
P(GA204/02/0407), Z(AV0Z5052915)
n3:cisloPeriodika
8-9
n3:dodaniDat
n4:2005
n3:domaciTvurceVysledku
n7:1420275 n7:4139151
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
559667
n3:idVysledku
RIV/68378050:_____/04:00000219
n3:jazykVysledku
n18:eng
n3:klicovaSlova
avian; sarcoma; immortalization
n3:klicoveSlovo
n11:avian n11:immortalization n11:sarcoma
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A7EB2D2028A2]
n3:nazevZdroje
In Vitro - Cellular and Developmental Biology. Animal Section
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n13:GA204%2F02%2F0407
n3:rokUplatneniVysledku
n4:2004
n3:svazekPeriodika
40
n3:tvurceVysledku
Trtková, Kateřina Plachý, Jiří
n3:zamer
n10:AV0Z5052915
s:issn
1071-2690
s:numberOfPages
8