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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F03%3A23033200%21RIV%2F2004%2FAV0%2FA23004%2FN
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Patterns of tumor susceptibility in different organs are widely divergent in mouse strains: one strain may be highly susceptible to tumors in one organ but resistant in another organ, whereas another strain may exhibit the opposite pattern (P. Demant, Semin. Cancer Biol., 3: 159-166, 1992). Therefore, susceptibility to tumors in different organs is assumed to be controlled by different sets of genes. On the other hand, many oncogenes and tumor suppressor genes are mutated in tumors from different organs, indicating that similar tumorigenic pathways operate in various tissues. To obtain insight into the interactions of susceptibility genes with one of such pathways, we compared tumorigenesis in intestine and mammary gland in recombinant congenic strains (RCSs) carrying the Apc(Min) mutation, affecting the Writ pathway. The presence of Apc(Min) increased considerably the incidence of intestinal and mammary tumors. The individual RCSs differed in the number and latency of Apc(Min)-induced intestinal and Patterns of tumor susceptibility in different organs are widely divergent in mouse strains: one strain may be highly susceptible to tumors in one organ but resistant in another organ, whereas another strain may exhibit the opposite pattern (P. Demant, Semin. Cancer Biol., 3: 159-166, 1992). Therefore, susceptibility to tumors in different organs is assumed to be controlled by different sets of genes. On the other hand, many oncogenes and tumor suppressor genes are mutated in tumors from different organs, indicating that similar tumorigenic pathways operate in various tissues. To obtain insight into the interactions of susceptibility genes with one of such pathways, we compared tumorigenesis in intestine and mammary gland in recombinant congenic strains (RCSs) carrying the Apc(Min) mutation, affecting the Writ pathway. The presence of Apc(Min) increased considerably the incidence of intestinal and mammary tumors. The individual RCSs differed in the number and latency of Apc(Min)-induced intestinal and
dcterms:title
Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland. Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland.
skos:prefLabel
Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland. Opposite effects of modifiers of the Apc(Min) mutation in intestine and mammary gland.
skos:notation
RIV/68378050:_____/03:23033200!RIV/2004/AV0/A23004/N
n3:strany
4533;4537
n3:aktivita
n12:Z
n3:aktivity
Z(AV0Z5052915)
n3:cisloPeriodika
63
n3:dodaniDat
n14:2004
n3:domaciTvurceVysledku
n4:1633406
n3:druhVysledku
n6:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
619644
n3:idVysledku
RIV/68378050:_____/03:23033200
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Recombinant congenic strains; primary breast cancers; APC gene
n3:klicoveSlovo
n13:Recombinant%20congenic%20strains n13:primary%20breast%20cancers n13:APC%20gene
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[9A17A1DA6034]
n3:nazevZdroje
Cancer research
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n14:2003
n3:svazekPeriodika
2003
n3:tvurceVysledku
Piskorowska, J. Pilčík, Tomáš Krysiak, E. Sitarz, M. Czarnomska, A. Demant, P.
n3:zamer
n11:AV0Z5052915
s:issn
0008-5472
s:numberOfPages
5