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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F03%3A23033176%21RIV%2F2004%2FAV0%2FA23004%2FN
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Hybridization of established dendritic cell lines with tumour cells represents a prospective technology for the construction of antitumour vaccines. Experiments were designed to examine whether administration of cell populations prepared by fusion of HPV 16-associated tumour TC-1 cells with dendritic cell line DC2.4 could be used for treatment of TC-1 tumours growing in syngeneic mice. The therapeutic potency of TC-1/DC2.4 fusion vaccine administered 24 h after fusion and that of TC-1/DC2.4 hybrid cells selected for 3 weeks in HAT-containing medium was tested. It has been found that administration of both types of fusion vaccines at the site of growing TC-1 tumour transplants significantly inhibited tumour growth with regard to the percentage of tumour-bearing mice and to the size of the transplanted tumours. Peritumoral administration of the DC2.4 cells alone also reduced the size of growing TC-1 tumours, but not the percentage of the tumour-bearing mice. Although in the groups of mice treated with f Hybridization of established dendritic cell lines with tumour cells represents a prospective technology for the construction of antitumour vaccines. Experiments were designed to examine whether administration of cell populations prepared by fusion of HPV 16-associated tumour TC-1 cells with dendritic cell line DC2.4 could be used for treatment of TC-1 tumours growing in syngeneic mice. The therapeutic potency of TC-1/DC2.4 fusion vaccine administered 24 h after fusion and that of TC-1/DC2.4 hybrid cells selected for 3 weeks in HAT-containing medium was tested. It has been found that administration of both types of fusion vaccines at the site of growing TC-1 tumour transplants significantly inhibited tumour growth with regard to the percentage of tumour-bearing mice and to the size of the transplanted tumours. Peritumoral administration of the DC2.4 cells alone also reduced the size of growing TC-1 tumours, but not the percentage of the tumour-bearing mice. Although in the groups of mice treated with f
dcterms:title
Immunotherapy of HPV-16-associated tumours with tumour cell line/dendritic cell line (TC-1/DC2.4) hybrid vaccines. Immunotherapy of HPV-16-associated tumours with tumour cell line/dendritic cell line (TC-1/DC2.4) hybrid vaccines.
skos:prefLabel
Immunotherapy of HPV-16-associated tumours with tumour cell line/dendritic cell line (TC-1/DC2.4) hybrid vaccines. Immunotherapy of HPV-16-associated tumours with tumour cell line/dendritic cell line (TC-1/DC2.4) hybrid vaccines.
skos:notation
RIV/68378050:_____/03:23033176!RIV/2004/AV0/A23004/N
n3:strany
203;206
n3:aktivita
n15:Z
n3:aktivity
Z(AV0Z5052915)
n3:cisloPeriodika
49
n3:dodaniDat
n6:2004
n3:domaciTvurceVysledku
n5:3714977 n5:1723758 n5:6215319 n5:4531140
n3:druhVysledku
n12:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
609842
n3:idVysledku
RIV/68378050:_____/03:23033176
n3:jazykVysledku
n4:eng
n3:klicovaSlova
HPV16; dendritic cells; fusion
n3:klicoveSlovo
n11:fusion n11:dendritic%20cells n11:HPV16
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[95444869C19D]
n3:nazevZdroje
Folia Biologica
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n6:2003
n3:svazekPeriodika
2003
n3:tvurceVysledku
Jandlová, Táňa Bieblová, Jana Šímová, Jana Bubeník, Jan
n3:zamer
n9:AV0Z5052915
s:issn
0015-5500
s:numberOfPages
4