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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F03%3A23033133%21RIV%2F2004%2FAV0%2FA23004%2FN
rdf:type
n15:Vysledek skos:Concept
dcterms:description
The jet injection technology was used for delivery of recombinant adeno-associated virus (rAAV).We tried to address some cell-targeting problems by using a new low-volume needleless jet-injection device teh Swiss Injector. First we tested, by electron microscopy, whether jet-injection would have any detrimental effect on rAAV particle integrity. Second, we compared transgene expression after infection of 293T cells with fired or control rAAV that expressed green fluorescent protein, beta-galactosidase, the B7.1 molecule and interleukin 2. Third an rAAV carring the genes coding for beta-gal was jet-injected into mouse subcutaneous tumours.This study demonstrated the applicability of the Swiss Injector for delivery of rAAV into tumour tissue without either vector particle integrity or the level of the transgenes expression being affected. The jet injection technology was used for delivery of recombinant adeno-associated virus (rAAV).We tried to address some cell-targeting problems by using a new low-volume needleless jet-injection device teh Swiss Injector. First we tested, by electron microscopy, whether jet-injection would have any detrimental effect on rAAV particle integrity. Second, we compared transgene expression after infection of 293T cells with fired or control rAAV that expressed green fluorescent protein, beta-galactosidase, the B7.1 molecule and interleukin 2. Third an rAAV carring the genes coding for beta-gal was jet-injected into mouse subcutaneous tumours.This study demonstrated the applicability of the Swiss Injector for delivery of rAAV into tumour tissue without either vector particle integrity or the level of the transgenes expression being affected.
dcterms:title
Delivery of recombinant adeno-associated virus by jet injection. Delivery of recombinant adeno-associated virus by jet injection.
skos:prefLabel
Delivery of recombinant adeno-associated virus by jet injection. Delivery of recombinant adeno-associated virus by jet injection.
skos:notation
RIV/68378050:_____/03:23033133!RIV/2004/AV0/A23004/N
n4:strany
687;691
n4:aktivita
n13:Z n13:P
n4:aktivity
P(NC5900), Z(AV0Z5052915)
n4:cisloPeriodika
5
n4:dodaniDat
n7:2004
n4:domaciTvurceVysledku
n5:5357985
n4:druhVysledku
n17:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
603013
n4:idVysledku
RIV/68378050:_____/03:23033133
n4:jazykVysledku
n18:eng
n4:klicovaSlova
jet injection; adeno-associated virus; gene therapy
n4:klicoveSlovo
n9:adeno-associated%20virus n9:jet%20injection n9:gene%20therapy
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[B24BDDE5D387]
n4:nazevZdroje
International Journal of Molecular Medicine
n4:obor
n12:EE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
5
n4:pocetUcastnikuAkce
0
n4:pocetZahranicnichUcastnikuAkce
0
n4:projekt
n8:NC5900
n4:rokUplatneniVysledku
n7:2003
n4:svazekPeriodika
12
n4:tvurceVysledku
Jinoch, P. Nellessen, T. Štokrová, Jitka Šmahel, M. Janouskova, O.
n4:zamer
n11:AV0Z5052915
s:issn
1107-3756
s:numberOfPages
5