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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F03%3A23033071%21RIV%2F2004%2FAV0%2FA23004%2FN
rdf:type
n3:Vysledek skos:Concept
dcterms:description
The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous cytotrophoblast cells. HLA-G can inhibit the killing mediated by NK cells via interaction with the inhibitory NK cell receptor LIR-1. Comparison of the sequence of the HLA-G molecule to other class I MHC proteins revealed two unique cysteine residues 42 and 147. Mutating these cysteine residues resulted in a dramatic decrease in LIR-1 Ig binding. The mutated HLA-G transfectants were less effective in the inhibition of NK killing. The involvement of the cysteine residues in the formation of HLA-G protein oligomers was demonstrated. The cysteine residue 42 is critical for the expression of such complexes. These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells. The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous cytotrophoblast cells. HLA-G can inhibit the killing mediated by NK cells via interaction with the inhibitory NK cell receptor LIR-1. Comparison of the sequence of the HLA-G molecule to other class I MHC proteins revealed two unique cysteine residues 42 and 147. Mutating these cysteine residues resulted in a dramatic decrease in LIR-1 Ig binding. The mutated HLA-G transfectants were less effective in the inhibition of NK killing. The involvement of the cysteine residues in the formation of HLA-G protein oligomers was demonstrated. The cysteine residue 42 is critical for the expression of such complexes. These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells.
dcterms:title
Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.
skos:prefLabel
Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.
skos:notation
RIV/68378050:_____/03:23033071!RIV/2004/AV0/A23004/N
n5:strany
1343;1351
n5:aktivita
n11:P n11:Z
n5:aktivity
P(LN00A026), Z(AV0Z5052915)
n5:cisloPeriodika
3
n5:dodaniDat
n14:2004
n5:domaciTvurceVysledku
n12:7776535
n5:druhVysledku
n10:J
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n15:predkladatel
n5:idSjednocenehoVysledku
601853
n5:idVysledku
RIV/68378050:_____/03:23033071
n5:jazykVysledku
n9:eng
n5:klicovaSlova
HLA-G; LIR-1; NK cells
n5:klicoveSlovo
n6:LIR-1 n6:NK%20cells n6:HLA-G
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[C15DE16BFA21]
n5:nazevZdroje
Journal of Immunology
n5:obor
n16:EC
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
12
n5:pocetUcastnikuAkce
0
n5:pocetZahranicnichUcastnikuAkce
0
n5:projekt
n8:LN00A026
n5:rokUplatneniVysledku
n14:2003
n5:svazekPeriodika
171
n5:tvurceVysledku
Hanna, J. Mandelboim, O. Achdout, H. Hořejší, Václav Baniyash, M. Gonen-Gross, T. Levy, O. Goldman-Wohl, D. Markel, G. Yagel, S. Gazit, R. Mizrahi, S.
n5:zamer
n18:AV0Z5052915
s:issn
0022-1767
s:numberOfPages
4