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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F02%3A23033175%21RIV%2F2004%2FAV0%2FA23004%2FN
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The strain BALB/cHeA (BALB/c) is a high producer, and STS/A (STS) a low producer of IgE after Leishmania major infection. We analyzed this strain difference using 20 recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% of genes of the strain STS on the BALB/c background. Strains CcS-16 and -20 exhibit a high and a low IgE level, respectively. In their F, hybrids with BALBIc we mapped nine Leishmania major response (Lmr) loci. Two of them we previously found to influence IgE level in CcS-5. IgE production in CcS-16 is controlled by loci on chromosomes 2, 10, 16 and 18 and in CcS-20 by loci on chromosomes 1, 3, 4, 5 and 8. The STS alleles of loci on chromosomes 1, 4, 5, 8 and 10 were associated with a low, whereas the STS alleles on chromosomes 16 and 18 with a high IgE production. The loci on chromosomes 2 and 3 have no apparent individual effect, but interact with the loci on chromosomes 10 and 1, respectively. The loci on chromosomes 10 and 18 were The strain BALB/cHeA (BALB/c) is a high producer, and STS/A (STS) a low producer of IgE after Leishmania major infection. We analyzed this strain difference using 20 recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% of genes of the strain STS on the BALB/c background. Strains CcS-16 and -20 exhibit a high and a low IgE level, respectively. In their F, hybrids with BALBIc we mapped nine Leishmania major response (Lmr) loci. Two of them we previously found to influence IgE level in CcS-5. IgE production in CcS-16 is controlled by loci on chromosomes 2, 10, 16 and 18 and in CcS-20 by loci on chromosomes 1, 3, 4, 5 and 8. The STS alleles of loci on chromosomes 1, 4, 5, 8 and 10 were associated with a low, whereas the STS alleles on chromosomes 16 and 18 with a high IgE production. The loci on chromosomes 2 and 3 have no apparent individual effect, but interact with the loci on chromosomes 10 and 1, respectively. The loci on chromosomes 10 and 18 were
dcterms:title
Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice.
skos:prefLabel
Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice.
skos:notation
RIV/68378050:_____/02:23033175!RIV/2004/AV0/A23004/N
n3:strany
187;195
n3:aktivita
n4:Z n4:P
n3:aktivity
P(GA310/00/0760), P(NM28), P(OK 394), Z(AV0Z5052915)
n3:cisloPeriodika
3
n3:dodaniDat
n17:2004
n3:domaciTvurceVysledku
n9:7092482 Vladimirov, Vladimir n9:1633406 n9:6111122 n9:2463490
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
663318
n3:idVysledku
RIV/68378050:_____/02:23033175
n3:jazykVysledku
n16:eng
n3:klicovaSlova
IgE; quantitative trait; Leishmania major,
n3:klicoveSlovo
n5:quantitative%20trait n5:IgE n5:Leishmania%20major
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[7CDE30B6C276]
n3:nazevZdroje
Genes and immunity
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
10
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n8:OK%20394 n8:GA310%2F00%2F0760 n8:NM28
n3:rokUplatneniVysledku
n17:2002
n3:svazekPeriodika
2002
n3:tvurceVysledku
Vladimirov, Vladimir Vojtíšková, Jarmila Svobodová, M. Volf, P. Demant, P. Pilčík, Tomáš Engová, J. Bádalová, J. Lipoldová, Marie Havelková, Helena
n3:zamer
n12:AV0Z5052915
s:issn
1466-4879
s:numberOfPages
9