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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F02%3A23033137%21RIV%2F2004%2FAV0%2FA23004%2FN
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Iron deprivation specifically induces apoptosis in some tumor cells while other tumor cells are resistant. We have shown previously that the p53 pathway, including p53 activation and subsequent regulation of the expression of relevant genes of the bcl-2 family such as bax and bcl-2, is not involved in apoptosis induction by iron deprivation. In the present study we compared the activity of caspase-3 and caspase-9 in sensitive (38C13) versus resistant (EL4) cells under control and iron-depriving conditions. Iron deprivation resulted in a significant increase of the caspase-3 activity in sensitive but not in resistant cells. Similarly, we detected caspase-9 activation under iron deprivation in sensitive but not in resistant cells. We also compared the distribution of some proteins of the Bcl-2 family in sensitive versus resistant cells under control and iron-depriving conditions. Confocal microscopy revealed that iron deprivation resulted in Bax protein translocation from the cytosol to mitochondria in Iron deprivation specifically induces apoptosis in some tumor cells while other tumor cells are resistant. We have shown previously that the p53 pathway, including p53 activation and subsequent regulation of the expression of relevant genes of the bcl-2 family such as bax and bcl-2, is not involved in apoptosis induction by iron deprivation. In the present study we compared the activity of caspase-3 and caspase-9 in sensitive (38C13) versus resistant (EL4) cells under control and iron-depriving conditions. Iron deprivation resulted in a significant increase of the caspase-3 activity in sensitive but not in resistant cells. Similarly, we detected caspase-9 activation under iron deprivation in sensitive but not in resistant cells. We also compared the distribution of some proteins of the Bcl-2 family in sensitive versus resistant cells under control and iron-depriving conditions. Confocal microscopy revealed that iron deprivation resulted in Bax protein translocation from the cytosol to mitochondria in
dcterms:title
Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases. Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases.
skos:prefLabel
Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases. Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases.
skos:notation
RIV/68378050:_____/02:23033137!RIV/2004/AV0/A23004/N
n3:strany
2
n3:aktivita
n11:Z
n3:aktivity
Z(AV0Z5052915)
n3:dodaniDat
n5:2004
n3:domaciTvurceVysledku
n8:1207393 n8:9013431 n8:7020597 n8:1758330 n8:6608035
n3:druhVysledku
n18:D
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
638729
n3:idVysledku
RIV/68378050:_____/02:23033137
n3:jazykVysledku
n16:eng
n3:klicovaSlova
apoptosis induction; caspase activation; Bax translocation
n3:klicoveSlovo
n9:Bax%20translocation n9:apoptosis%20induction n9:caspase%20activation
n3:kontrolniKodProRIV
[0D63A8D866BB]
n3:mistoKonaniAkce
Reims [FR]
n3:mistoVydani
UK
n3:nazevZdroje
Abstracts of the 25th Meeting of the European Study Group for Cell Proliferation (ESGCP).
n3:obor
n12:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n5:2002
n3:tvurceVysledku
Kovář, Jan Truksa, Jaroslav Ehrlichová, Marie Štýbrová, Hana Koc, Michal
n3:typAkce
n15:WRD
n3:zahajeniAkce
2002-10-24+02:00
n3:zamer
n10:AV0Z5052915
s:numberOfPages
2
n17:hasPublisher
Blackwell Publishing