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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F02%3A23033134%21RIV%2F2004%2FGA0%2FA23004%2FN
rdf:type
n16:Vysledek skos:Concept
dcterms:description
We studied the effects of thiol availability on apoptosis induction in B-cell lymphoma 38C13, T-cell lymphoma EL4, and also other cells. Compounds with a free SH group are required for survival and growth of 38C13 cells but not of EL4 cells. Thiol deprivation (2-mercaptoethanol concentrations about 0.3 microM and lower) induced apoptosis in 38C13 cells. On the other hand, thiol excess (2-mercaptoethanol concentrations higher than 300 microM) induced apoptosis in 38C13 cells and EL4 cells as well as in other cells (e.g. Raji, HeLa). L-cystine and non-thiol antioxidant ascorbic acid were unable to support survival of 38C13 cells. Ascorbic acid induced cell death at concentrations higher than 600 microM. Thiol cross-linking compound diamide (100 microM and higher) abrogated the survival-supporting effect of 2-mercaptoethanol (50 microM). Apoptosis induction by thiol deprivation and by thiol excess was not directly related to a specific significant change in the p53 level or p53 activation. Apoptosis indu We studied the effects of thiol availability on apoptosis induction in B-cell lymphoma 38C13, T-cell lymphoma EL4, and also other cells. Compounds with a free SH group are required for survival and growth of 38C13 cells but not of EL4 cells. Thiol deprivation (2-mercaptoethanol concentrations about 0.3 microM and lower) induced apoptosis in 38C13 cells. On the other hand, thiol excess (2-mercaptoethanol concentrations higher than 300 microM) induced apoptosis in 38C13 cells and EL4 cells as well as in other cells (e.g. Raji, HeLa). L-cystine and non-thiol antioxidant ascorbic acid were unable to support survival of 38C13 cells. Ascorbic acid induced cell death at concentrations higher than 600 microM. Thiol cross-linking compound diamide (100 microM and higher) abrogated the survival-supporting effect of 2-mercaptoethanol (50 microM). Apoptosis induction by thiol deprivation and by thiol excess was not directly related to a specific significant change in the p53 level or p53 activation. Apoptosis indu
dcterms:title
Apoptosis induction in lymphoma cells: thiol deprivation versus thiol excess. Apoptosis induction in lymphoma cells: thiol deprivation versus thiol excess.
skos:prefLabel
Apoptosis induction in lymphoma cells: thiol deprivation versus thiol excess. Apoptosis induction in lymphoma cells: thiol deprivation versus thiol excess.
skos:notation
RIV/68378050:_____/02:23033134!RIV/2004/GA0/A23004/N
n3:strany
58;68
n3:aktivita
n11:Z n11:P
n3:aktivity
P(GA301/01/0041), P(GA301/97/1029), Z(AV0Z5052915)
n3:cisloPeriodika
2
n3:dodaniDat
n12:2004
n3:domaciTvurceVysledku
n9:6146872 n9:1207393 n9:1758330 n9:9126708 n9:6608035
n3:druhVysledku
n14:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
638730
n3:idVysledku
RIV/68378050:_____/02:23033134
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Apoptosis induction; thiol deprivation; thiol excess
n3:klicoveSlovo
n15:Apoptosis%20induction n15:thiol%20deprivation n15:thiol%20excess
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[9488BF8482B9]
n3:nazevZdroje
Folia Biologica
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n4:GA301%2F01%2F0041 n4:GA301%2F97%2F1029
n3:rokUplatneniVysledku
n12:2002
n3:svazekPeriodika
48
n3:tvurceVysledku
Kovář, Jan Truksa, Jaroslav Valenta, Tomáš Štýbrová, Hana Spěváková, Kateřina
n3:zamer
n10:AV0Z5052915
s:issn
0015-5500
s:numberOfPages
11