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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F02%3A23033123%21RIV%2F2004%2FGA0%2FA23004%2FN
rdf:type
n14:Vysledek skos:Concept
dcterms:description
We prepared monoclonal antibodies against lipid rafts from the rat basophilic leukemia cell line, RBL-2H3. One of the antibodies was found to recognize a novel glycosylphosphatidylinositol-anchored plasma membrane glycoprotein of 250 amino acids, designated TEC-21, containing a cysteine-rich domain homologous to those found in the urokinase plasminogen activator receptor/Ly6/snake neurotoxin family. The TEC-21 is abundant on the surface of RBL-2H3 cells (>106 molecules/cell) but is absent in numerous rat tissues except for testes. Aggregation of TEC-21 on RBL-2H3 cells induced a rapid increase in tyrosine phosphorylation of several substrates including Syk kinase and LAT adaptor, calcium flux, and release of secretory components. TEC-21-induced activation events were also observed in Fce receptorI-negative mutants of RBL-2H3 cells. The combined data suggest that TEC-21 is a novel lipid raft component of RBL-2H3 cells whose aggregation induces activation independently of Fce receptorI. We prepared monoclonal antibodies against lipid rafts from the rat basophilic leukemia cell line, RBL-2H3. One of the antibodies was found to recognize a novel glycosylphosphatidylinositol-anchored plasma membrane glycoprotein of 250 amino acids, designated TEC-21, containing a cysteine-rich domain homologous to those found in the urokinase plasminogen activator receptor/Ly6/snake neurotoxin family. The TEC-21 is abundant on the surface of RBL-2H3 cells (>106 molecules/cell) but is absent in numerous rat tissues except for testes. Aggregation of TEC-21 on RBL-2H3 cells induced a rapid increase in tyrosine phosphorylation of several substrates including Syk kinase and LAT adaptor, calcium flux, and release of secretory components. TEC-21-induced activation events were also observed in Fce receptorI-negative mutants of RBL-2H3 cells. The combined data suggest that TEC-21 is a novel lipid raft component of RBL-2H3 cells whose aggregation induces activation independently of Fce receptorI.
dcterms:title
A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor. A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor.
skos:prefLabel
A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor. A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor.
skos:notation
RIV/68378050:_____/02:23033123!RIV/2004/GA0/A23004/N
n3:strany
213;223
n3:aktivita
n4:P n4:Z
n3:aktivity
P(GA204/00/0204), P(GA310/00/0205), P(GV312/96/K205), P(IAA5052005), P(IAA7052006), P(LN00A026), Z(AV0Z5052915)
n3:cisloPeriodika
2
n3:dodaniDat
n9:2004
n3:domaciTvurceVysledku
n12:1820648 n12:6550789 n12:5182581
n3:druhVysledku
n7:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
637134
n3:idVysledku
RIV/68378050:_____/02:23033123
n3:jazykVysledku
n16:eng
n3:klicovaSlova
mast cell; plasma membrane; IgE
n3:klicoveSlovo
n6:IgE n6:mast%20cell n6:plasma%20membrane
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[97C5D0468765]
n3:nazevZdroje
International Immunology
n3:obor
n15:EC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n8:GV312%2F96%2FK205 n8:IAA5052005 n8:GA204%2F00%2F0204 n8:IAA7052006 n8:LN00A026 n8:GA310%2F00%2F0205
n3:rokUplatneniVysledku
n9:2002
n3:svazekPeriodika
14
n3:tvurceVysledku
Dráberová, Lubica Hálová, Ivana Dráber, Petr
n3:zamer
n18:AV0Z5052915
s:issn
1460-2377
s:numberOfPages
11