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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F01%3A23010445%21RIV%2F2003%2FAV0%2FA23003%2FN
rdf:type
n10:Vysledek skos:Concept
dcterms:description
The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature cells belonging to at least eight different leneages. We found that the leucine zipper region (LZR) of the v-Myb transcription factor affets the lineage commitment of myeloid progenitors. We propose that Myb LZR can function as a molecular switch affecting expression of lineage specifying factors and directing the development of hematopoietic progenitors into either myeloid or erythroid lineages. The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature cells belonging to at least eight different leneages. We found that the leucine zipper region (LZR) of the v-Myb transcription factor affets the lineage commitment of myeloid progenitors. We propose that Myb LZR can function as a molecular switch affecting expression of lineage specifying factors and directing the development of hematopoietic progenitors into either myeloid or erythroid lineages.
dcterms:title
The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors. The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors.
skos:prefLabel
The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors. The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors.
skos:notation
RIV/68378050:_____/01:23010445!RIV/2003/AV0/A23003/N
n3:strany
3668;3676
n3:aktivita
n8:P n8:Z
n3:aktivity
P(GV301/98/K042), P(IAA5052805), Z(AV0Z5052915)
n3:cisloPeriodika
N/A
n3:dodaniDat
n17:2003
n3:domaciTvurceVysledku
n4:3340848 n4:2739623 n4:7869924 n4:8465800 n4:8857857 n4:9407219 n4:4095901
n3:druhVysledku
n12:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
685246
n3:idVysledku
RIV/68378050:_____/01:23010445
n3:jazykVysledku
n18:eng
n3:klicovaSlova
hamatopoiesis; - commitment; - Myb
n3:klicoveSlovo
n7:hamatopoiesis n7:-%20Myb n7:-%20commitment
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[BC75E2A0B87C]
n3:nazevZdroje
Blood
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
9
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n11:GV301%2F98%2FK042 n11:IAA5052805
n3:rokUplatneniVysledku
n17:2001
n3:svazekPeriodika
98
n3:tvurceVysledku
Zenke, M. Dvořáková, Marta Dvořák, Michal Karafiát, Vít Králová, Jarmila Pajer, Petr Hořejší, Z. Čermák, Vladimír Bartůněk, Petr
n3:zamer
n13:AV0Z5052915
s:issn
0006-4971
s:numberOfPages
9