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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F01%3A23010339%21RIV%2F2003%2FAV0%2FA23003%2FN
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The capacity to present antigens, activate naive T cells and induce primary cellular immunity make DC attractive vehicles for delivery of therapeutic cancer vaccines. Genetically modified DC vaccines can be prepared by transfection with polynucleotides coding for oncoproteins, immunostimulatory cytokines and/or co-stimulatory molecules, transduction with recombinant viral vectors encoding these molecules and tumour cell-DC fusion. The therapeutic effects of these vaccines in vitro and in vivo are discussed. The capacity to present antigens, activate naive T cells and induce primary cellular immunity make DC attractive vehicles for delivery of therapeutic cancer vaccines. Genetically modified DC vaccines can be prepared by transfection with polynucleotides coding for oncoproteins, immunostimulatory cytokines and/or co-stimulatory molecules, transduction with recombinant viral vectors encoding these molecules and tumour cell-DC fusion. The therapeutic effects of these vaccines in vitro and in vivo are discussed.
dcterms:title
Genetically modified dendritic cell-based cancer vaccines. Genetically modified dendritic cell-based cancer vaccines.
skos:prefLabel
Genetically modified dendritic cell-based cancer vaccines. Genetically modified dendritic cell-based cancer vaccines.
skos:notation
RIV/68378050:_____/01:23010339!RIV/2003/AV0/A23003/N
n5:strany
153;155
n5:aktivita
n13:P n13:Z
n5:aktivity
P(NC5526), Z(AV0Z5052915)
n5:cisloPeriodika
5
n5:dodaniDat
n15:2003
n5:domaciTvurceVysledku
n11:6215319
n5:druhVysledku
n12:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n10:predkladatel
n5:idSjednocenehoVysledku
681081
n5:idVysledku
RIV/68378050:_____/01:23010339
n5:jazykVysledku
n9:eng
n5:klicovaSlova
dendritic cells; - cancer vaccines
n5:klicoveSlovo
n6:-%20cancer%20vaccines n6:dendritic%20cells
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[42066C848875]
n5:nazevZdroje
Folia Biologica (Praha)
n5:obor
n7:EB
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
1
n5:pocetUcastnikuAkce
0
n5:pocetZahranicnichUcastnikuAkce
0
n5:projekt
n17:NC5526
n5:rokUplatneniVysledku
n15:2001
n5:svazekPeriodika
47
n5:tvurceVysledku
Bubeník, Jan
n5:zamer
n16:AV0Z5052915
s:issn
0015-5500
s:numberOfPages
3