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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F01%3A23010279%21RIV%2F2003%2FAV0%2FA23003%2FN
rdf:type
n11:Vysledek skos:Concept
dcterms:description
We analyzed the experssion of carbonic anhydrase CA9 and CA12genes in a large sample of cancer cell lines, fresh and archival cell specimens, and normal human tissues. Expression of CA9 and CA12 in normal adult tissues was detected only in highly specialized cells and their expression did not overlap. In Von Hippel-Lindau (VHL)-defective tumors and/or under hypoxic conditions, CA9 and CA12 genes are overexpressed. We suggest that expression of CA9 and CA12 may be required for tumor progression. We analyzed the experssion of carbonic anhydrase CA9 and CA12genes in a large sample of cancer cell lines, fresh and archival cell specimens, and normal human tissues. Expression of CA9 and CA12 in normal adult tissues was detected only in highly specialized cells and their expression did not overlap. In Von Hippel-Lindau (VHL)-defective tumors and/or under hypoxic conditions, CA9 and CA12 genes are overexpressed. We suggest that expression of CA9 and CA12 may be required for tumor progression.
dcterms:title
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.
skos:prefLabel
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.
skos:notation
RIV/68378050:_____/01:23010279!RIV/2003/AV0/A23003/N
n3:strany
905;919
n3:aktivita
n6:P n6:Z
n3:aktivity
P(GA301/99/0356), Z(AV0Z5052915)
n3:cisloPeriodika
3
n3:dodaniDat
n10:2003
n3:domaciTvurceVysledku
n18:3046575
n3:druhVysledku
n9:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
680085
n3:idVysledku
RIV/68378050:_____/01:23010279
n3:jazykVysledku
n16:eng
n3:klicovaSlova
carbonic anhydrase 9; - hypoxia; - human cancer
n3:klicoveSlovo
n5:-%20hypoxia n5:-%20human%20cancer n5:carbonic%20anhydrase%209
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[F76A70E74A0A]
n3:nazevZdroje
American Journal of Pathology
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
15
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n8:GA301%2F99%2F0356
n3:rokUplatneniVysledku
n10:2001
n3:svazekPeriodika
158
n3:tvurceVysledku
Tarasova, N. Lerman, M. I. Sly, W. Waheed, A. Proescholdt, M. A. Oldfield, E. H. Ivanova, A. Lee, J. Ivanov, S. Weirich, G. Závada, Jan Danilkovitch-Miagkova, A. Stanbridge, E. J. Shu-Yuan, L. Merrill, M. J.
n3:zamer
n14:AV0Z5052915
s:issn
0002-9440
s:numberOfPages
15