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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F14%3A00435644%21RIV15-GA0-68378041
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The cells were treated for 24 h with B[a]P (1 μM, 10 μM, 25 μM) and EOMs (1 μg/ml, 10 μg/ml, 25 μg/ml). 25 μM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts. The cells were treated for 24 h with B[a]P (1 μM, 10 μM, 25 μM) and EOMs (1 μg/ml, 10 μg/ml, 25 μg/ml). 25 μM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts.
dcterms:title
Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants
skos:prefLabel
Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants
skos:notation
RIV/68378041:_____/14:00435644!RIV15-GA0-68378041
n3:aktivita
n11:I n11:P
n3:aktivity
I, P(GAP503/11/0084)
n3:cisloPeriodika
MAY-JUN 2014
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
Beskid, Olena n6:2944812 n6:3165000 n6:8569126 n6:2279312 n6:8406332 n6:4106202 Tabashidze, Nana
n3:druhVysledku
n9:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
32758
n3:idVysledku
RIV/68378041:_____/14:00435644
n3:jazykVysledku
n18:eng
n3:klicovaSlova
benzo[a]pyrene; chromosome aberrations; double-strand DNA breaks
n3:klicoveSlovo
n7:chromosome%20aberrations n7:benzo%5Ba%5Dpyrene n7:double-strand%20DNA%20breaks
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[8002F4CE3E82]
n3:nazevZdroje
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
n3:obor
n17:DN
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:projekt
n5:GAP503%2F11%2F0084
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
763-764
n3:tvurceVysledku
Líbalová, Helena Beskid, Olena Šrám, Radim Rössner ml., Pavel Topinka, Jan Tabashidze, Nana Rössnerová, Andrea Uhlířová, Kateřina
n3:wos
000336694800004
s:issn
0027-5107
s:numberOfPages
11
n8:doi
10.1016/j.mrfmmm.2014.03.006