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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F14%3A00435536%21RIV15-AV0-68378041
rdf:type
n14:Vysledek skos:Concept
dcterms:description
A low-molecular weight dialyzable leukocyte extract (called transfer factor) has been used for many years in clinic to improve or modulate immune response. However, the mechanism of its action remained obscure. Here we showed that transfer factor modulates the production of various cytokines by activated T cells and that the most profound immunoregulatory effect of transfer factort can be seen on the development of Th17 cells and interleukin-17 productiion. Transfer factor significantly enhanced the production of proinflammatory cytokine IL-17. A low-molecular weight dialyzable leukocyte extract (called transfer factor) has been used for many years in clinic to improve or modulate immune response. However, the mechanism of its action remained obscure. Here we showed that transfer factor modulates the production of various cytokines by activated T cells and that the most profound immunoregulatory effect of transfer factort can be seen on the development of Th17 cells and interleukin-17 productiion. Transfer factor significantly enhanced the production of proinflammatory cytokine IL-17.
dcterms:title
A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production
skos:prefLabel
A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production
skos:notation
RIV/68378041:_____/14:00435536!RIV15-AV0-68378041
n3:aktivita
n16:I n16:P
n3:aktivity
I, P(LO1309)
n3:cisloPeriodika
6
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n9:3650871 n9:5695678 n9:6947891 n9:9565612 n9:7357354 n9:2767198
n3:druhVysledku
n17:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
803
n3:idVysledku
RIV/68378041:_____/14:00435536
n3:jazykVysledku
n4:eng
n3:klicovaSlova
enzyme-linked immunosorbent assay; interferon; interleukin
n3:klicoveSlovo
n11:enzyme-linked%20immunosorbent%20assay n11:interleukin n11:interferon
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[188AC57C0902]
n3:nazevZdroje
Folia Biologica
n3:obor
n10:EC
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n12:LO1309
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
60
n3:tvurceVysledku
Zajícová, Alena Chudičková, Milada Krulová, Magdaléna Holáň, Vladimír Javorková, Eliška Trošan, Peter
n3:wos
000347748000001
s:issn
0015-5500
s:numberOfPages
8