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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F14%3A00432995%21RIV15-GA0-68378041
rdf:type
n12:Vysledek skos:Concept
dcterms:description
The aim of this study was to investigate the effects of systemically administered bone-marrow-derived mesenchymal stromal cells (MSCs) on the early acute phase of inflammation in the alkali-burned eye. Mice with damaged eyes were either untreated or treated 24?h after the injury with an intravenous administration of fluorescent-dye-labeled MSCs that were unstimulated or pretreated with interleukin-1α (IL-1α), transforming growth factor-β (TGF-β), or interferon-γ (IFN-γ). Analysis of cell suspensions prepared from the eyes of treated mice on day 3 after the alkali burn revealed that MSCs specifically migrated to the damaged eye and that the number of labeled MSCs was more than 30-times higher in damaged eyes compared with control eyes. The study of the composition of the leukocyte populations within the damaged eyes showed that all types of tested MSCs slightly decreased the number of infiltrating lymphoid and myeloid cells, but only MSCs pretreated with IFN-γ significantly decreased the percentage of eye-infiltrating cells with a more profound effect on myeloid cells. The aim of this study was to investigate the effects of systemically administered bone-marrow-derived mesenchymal stromal cells (MSCs) on the early acute phase of inflammation in the alkali-burned eye. Mice with damaged eyes were either untreated or treated 24?h after the injury with an intravenous administration of fluorescent-dye-labeled MSCs that were unstimulated or pretreated with interleukin-1α (IL-1α), transforming growth factor-β (TGF-β), or interferon-γ (IFN-γ). Analysis of cell suspensions prepared from the eyes of treated mice on day 3 after the alkali burn revealed that MSCs specifically migrated to the damaged eye and that the number of labeled MSCs was more than 30-times higher in damaged eyes compared with control eyes. The study of the composition of the leukocyte populations within the damaged eyes showed that all types of tested MSCs slightly decreased the number of infiltrating lymphoid and myeloid cells, but only MSCs pretreated with IFN-γ significantly decreased the percentage of eye-infiltrating cells with a more profound effect on myeloid cells.
dcterms:title
Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-γ-Treated Mesenchymal Stromal Cells Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-γ-Treated Mesenchymal Stromal Cells
skos:prefLabel
Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-γ-Treated Mesenchymal Stromal Cells Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-γ-Treated Mesenchymal Stromal Cells
skos:notation
RIV/68378041:_____/14:00432995!RIV15-GA0-68378041
n3:aktivita
n17:P n17:I
n3:aktivity
I, P(GA14-12580S), P(GAP301/11/1568), P(GAP304/11/0653)
n3:cisloPeriodika
20
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
n5:5695678 n5:7357354 n5:2767198 n5:6947891 n5:9565612
n3:druhVysledku
n15:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
30225
n3:idVysledku
RIV/68378041:_____/14:00432995
n3:jazykVysledku
n18:eng
n3:klicovaSlova
mesenchymal stromal cells; nitric oxide; transforming growth factor beta
n3:klicoveSlovo
n16:transforming%20growth%20factor%20beta n16:nitric%20oxide n16:mesenchymal%20stromal%20cells
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4469738F7909]
n3:nazevZdroje
Stem Cells and Development
n3:obor
n10:EC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n6:GA14-12580S n6:GAP304%2F11%2F0653 n6:GAP301%2F11%2F1568
n3:rokUplatneniVysledku
n4:2014
n3:svazekPeriodika
23
n3:tvurceVysledku
Zajícová, Alena Krulová, Magdaléna Javorková, Eliška Trošan, Peter Hájková, M. Holáň, Vladimír
n3:wos
000342614300008
s:issn
1547-3287
s:numberOfPages
11
n13:doi
10.1089/scd.2013.0568