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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F14%3A00432596%21RIV15-GA0-68378041
rdf:type
n10:Vysledek skos:Concept
dcterms:description
We compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent transcriptional changes of selected target genes in human lung epithelial A549 cells incubated for 24 h, either with extractable organic matter (EOMs) from airborne particles <2.5 μm (PM2.5) Our results suggested inhibition of formation of B[a]P-induced DNA adducts compared to individual B[a]P, probably attributable to competitive inhibition by other non-genotoxic EOM components. We compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent transcriptional changes of selected target genes in human lung epithelial A549 cells incubated for 24 h, either with extractable organic matter (EOMs) from airborne particles <2.5 μm (PM2.5) Our results suggested inhibition of formation of B[a]P-induced DNA adducts compared to individual B[a]P, probably attributable to competitive inhibition by other non-genotoxic EOM components.
dcterms:title
Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
skos:prefLabel
Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
skos:notation
RIV/68378041:_____/14:00432596!RIV15-GA0-68378041
n3:aktivita
n15:I n15:P
n3:aktivity
I, P(GAP503/11/0142)
n3:cisloPeriodika
3
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n8:3119971 n8:2279312 n8:8569126 n8:2944812 n8:8168334 n8:8406332
n3:druhVysledku
n17:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
18156
n3:idVysledku
RIV/68378041:_____/14:00432596
n3:jazykVysledku
n7:eng
n3:klicovaSlova
air pollutin; DNA adducts; complex mixtures
n3:klicoveSlovo
n4:air%20pollutin n4:complex%20mixtures n4:DNA%20adducts
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[DEAECAD95F58]
n3:nazevZdroje
Toxicology Letters
n3:obor
n16:DN
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
10
n3:projekt
n6:GAP503%2F11%2F0142
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
225
n3:tvurceVysledku
Schmuczerová, Jana Machala, M. Kléma, J. Uhlířová, Kateřina Líbalová, Helena Milcová, Alena Topinka, Jan Krčková, S. Cigánek, M. Šrám, Radim
n3:wos
000331725400003
s:issn
0378-4274
s:numberOfPages
8
n14:doi
10.1016/j.toxlet.2014.01.028