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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F14%3A00397918%21RIV15-GA0-68378041
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The objective of this study was to investigate the cell-adhesive properties of biomimetic ligands, such as laminin-derived Ac-CGGASIKVAVS-OH (SIKVAV) peptide and fibronectin subunits (Fn), as well as small molecules exemplified by 2-mercaptoethanol (ME) and cysteine (Cys), immobilized on a copolymer of 2-hydroxyethyl methacrylate (HEMA) with 2-aminoethyl methacrylate (AEMA) by a maleimide-thiol coupling reaction. The results show that the immobilization of SIKVAV and Fn-subunits onto superporous P(HEMA-AEMA) hydrogels via a GMBS coupling reaction improves cell adhesive properties. The high proliferative activity observed on Fn-modified hydrogels suggests that the immobilized Fn-subunits maintain their bioactivity and thus represent a promising tool for application in tissue engineering The objective of this study was to investigate the cell-adhesive properties of biomimetic ligands, such as laminin-derived Ac-CGGASIKVAVS-OH (SIKVAV) peptide and fibronectin subunits (Fn), as well as small molecules exemplified by 2-mercaptoethanol (ME) and cysteine (Cys), immobilized on a copolymer of 2-hydroxyethyl methacrylate (HEMA) with 2-aminoethyl methacrylate (AEMA) by a maleimide-thiol coupling reaction. The results show that the immobilization of SIKVAV and Fn-subunits onto superporous P(HEMA-AEMA) hydrogels via a GMBS coupling reaction improves cell adhesive properties. The high proliferative activity observed on Fn-modified hydrogels suggests that the immobilized Fn-subunits maintain their bioactivity and thus represent a promising tool for application in tissue engineering
dcterms:title
The use of new surface-modified poly(2-hydroxyethyl methacrylate) hydrogels in tissue engineering: Treatment of the surface with fibronectin subunits versus Ac-CGGASIKVAVS-OH, cysteine, and 2-mercaptoethanol modification The use of new surface-modified poly(2-hydroxyethyl methacrylate) hydrogels in tissue engineering: Treatment of the surface with fibronectin subunits versus Ac-CGGASIKVAVS-OH, cysteine, and 2-mercaptoethanol modification
skos:prefLabel
The use of new surface-modified poly(2-hydroxyethyl methacrylate) hydrogels in tissue engineering: Treatment of the surface with fibronectin subunits versus Ac-CGGASIKVAVS-OH, cysteine, and 2-mercaptoethanol modification The use of new surface-modified poly(2-hydroxyethyl methacrylate) hydrogels in tissue engineering: Treatment of the surface with fibronectin subunits versus Ac-CGGASIKVAVS-OH, cysteine, and 2-mercaptoethanol modification
skos:notation
RIV/68378041:_____/14:00397918!RIV15-GA0-68378041
n3:aktivita
n11:I n11:P
n3:aktivity
I, P(GA13-00939S), P(GAP304/11/0653), P(GAP304/11/0731)
n3:cisloPeriodika
7
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n6:6738109 n6:3580318 n6:6220533
n3:druhVysledku
n15:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
52319
n3:idVysledku
RIV/68378041:_____/14:00397918
n3:jazykVysledku
n9:eng
n3:klicovaSlova
2-hydroxyethyl methacrylate; IKVAV (Ile-Lys-Val-Ala-Val) peptide; fibronectin
n3:klicoveSlovo
n7:fibronectin n7:IKVAV%20%28Ile-Lys-Val-Ala-Val%29%20peptide n7:2-hydroxyethyl%20methacrylate
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[074D0502BAF4]
n3:nazevZdroje
Journal of Biomedical Materials Research. Part A
n3:obor
n18:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n10:GA13-00939S n10:GAP304%2F11%2F0653 n10:GAP304%2F11%2F0731
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
102
n3:tvurceVysledku
Kubinová, Šárka Proks, Vladimír Vaněček, Václav Syková, Eva Horák, Daniel Plichta, Zdeněk
n3:wos
000337570400028
s:issn
1549-3296
s:numberOfPages
9
n14:doi
10.1002/jbm.a.34910