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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F12%3A00385620%21RIV13-AV0-68378041
rdf:type
n12:Vysledek skos:Concept
dcterms:description
The Czech Republic has one of the highest incidence rates of colorectal cancer (CRC) worldwide. In the present study, we genotyped common variants in cell cycle and DNA repair genes to assess the influence of genetic variation on the CRC risk, in 614 hospital-based CRC cases and 614 matched controls. Despite a tendency towards a differential distribution of the variant allele frequencies for some cell cycle polymorphisms, none was significantly associated with CRC risk. We observed a differential distribution between cases and controls of major haplotypes arising from the four analysed variants in the TP53 gene. The Czech Republic has one of the highest incidence rates of colorectal cancer (CRC) worldwide. In the present study, we genotyped common variants in cell cycle and DNA repair genes to assess the influence of genetic variation on the CRC risk, in 614 hospital-based CRC cases and 614 matched controls. Despite a tendency towards a differential distribution of the variant allele frequencies for some cell cycle polymorphisms, none was significantly associated with CRC risk. We observed a differential distribution between cases and controls of major haplotypes arising from the four analysed variants in the TP53 gene.
dcterms:title
Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic
skos:prefLabel
Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic
skos:notation
RIV/68378041:_____/12:00385620!RIV13-AV0-68378041
n12:predkladatel
n20:ico%3A68378041
n4:aktivita
n9:P n9:Z
n4:aktivity
P(GA310/07/1430), Z(AV0Z50390512)
n4:dodaniDat
n13:2013
n4:domaciTvurceVysledku
n18:3009912
n4:druhVysledku
n19:B
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n5:predkladatel
n4:idSjednocenehoVysledku
137916
n4:idVysledku
RIV/68378041:_____/12:00385620
n4:jazykVysledku
n21:eng
n4:klicovaSlova
colorectal cancer; polymorphism; TP53 gene
n4:klicoveSlovo
n7:colorectal%20cancer n7:TP53%20gene n7:polymorphism
n4:kontrolniKodProRIV
[6E95A4C445EC]
n4:mistoVydani
Saarbrucken
n4:nazevZdroje
Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic
n4:obor
n11:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetStranKnihy
92
n4:pocetTvurcuVysledku
1
n4:projekt
n16:GA310%2F07%2F1430
n4:rokUplatneniVysledku
n13:2012
n4:tvurceVysledku
Poláková, Veronika
n4:zamer
n6:AV0Z50390512
s:numberOfPages
92
n17:hasPublisher
LAP LAMBERT Academic Publishing
n15:isbn
978-3-8465-8563-4