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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F12%3A00384005%21RIV13-AV0-68378041
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs mnesic functions. The histopathology of the disease is manifested by the accumulation of intracellular β-amyloid (Aβ) and subsequent formation of neuritic plaques as well as the presence neurofibrillary tangles in specific brain regions associated with learning and memory including the hippocampus. Our results show that increased dietary TrP intake reduces intraneuronal Aβ load in the 3xTg-AD mouse model of AD, suggesting that enhanced TrP intake and in consequence a potential increase in 5-HT neurotransmission may be effective in reducing plaque pathology in AD. Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs mnesic functions. The histopathology of the disease is manifested by the accumulation of intracellular β-amyloid (Aβ) and subsequent formation of neuritic plaques as well as the presence neurofibrillary tangles in specific brain regions associated with learning and memory including the hippocampus. Our results show that increased dietary TrP intake reduces intraneuronal Aβ load in the 3xTg-AD mouse model of AD, suggesting that enhanced TrP intake and in consequence a potential increase in 5-HT neurotransmission may be effective in reducing plaque pathology in AD.
dcterms:title
High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease. High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease.
skos:prefLabel
High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease. High tryptophan diet reduces CA1 intraneuronal ss-amyloid in the triple transgenic mouse model of Alzheimer's disease.
skos:notation
RIV/68378041:_____/12:00384005!RIV13-AV0-68378041
n13:predkladatel
n17:ico%3A68378041
n3:aktivita
n9:P n9:I n9:Z
n3:aktivity
I, P(GA305/08/1384), P(GA309/09/1696), P(GAP304/11/0184), Z(AV0Z50390703)
n3:cisloPeriodika
5
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
Rodríguez Arellano, Jose Julio
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
138983
n3:idVysledku
RIV/68378041:_____/12:00384005
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Alzheimer's disease; hippocampus; L-tryptophan diet
n3:klicoveSlovo
n4:L-tryptophan%20diet n4:Alzheimer%27s%20disease n4:hippocampus
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7199A6DEFF75]
n3:nazevZdroje
Aging Cell
n3:obor
n15:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n11:GAP304%2F11%2F0184 n11:GA309%2F09%2F1696 n11:GA305%2F08%2F1384
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
11
n3:tvurceVysledku
Rodríguez Arellano, Jose Julio Verkhratsky, A. Noristani, H. N.
n3:wos
000308871400010
n3:zamer
n19:AV0Z50390703
s:issn
1474-9718
s:numberOfPages
13
n7:doi
10.1111/j.1474-9726.2012.00845.x