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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F12%3A00383908%21RIV13-AV0-68378041
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Spinal cord injury triggers a complex set of events that lead to tissue healing without the restoration of normal function due to the poor regenerative capacity of the spinal cord. Among the range of strategies under investigation, cell-based therapies offer the most promising results, due to the multifactorial roles that these cells can fulfill. In this context, the role of biomaterials is gaining importance. Some of the candidate molecules for the future are discussed in view of the knowledge derived from studying the mechanisms that facilitate the intrinsic regenerative capacity of central nervous system neurons. The future challenge for the multidisciplinary teams working in the field is to translate the knowledge acquired in basic research into effective combinatorial therapies to be applied in the clinic. Spinal cord injury triggers a complex set of events that lead to tissue healing without the restoration of normal function due to the poor regenerative capacity of the spinal cord. Among the range of strategies under investigation, cell-based therapies offer the most promising results, due to the multifactorial roles that these cells can fulfill. In this context, the role of biomaterials is gaining importance. Some of the candidate molecules for the future are discussed in view of the knowledge derived from studying the mechanisms that facilitate the intrinsic regenerative capacity of central nervous system neurons. The future challenge for the multidisciplinary teams working in the field is to translate the knowledge acquired in basic research into effective combinatorial therapies to be applied in the clinic.
dcterms:title
Regenerative medicine for the treatment of spinal cord injury: more than just promises? Regenerative medicine for the treatment of spinal cord injury: more than just promises?
skos:prefLabel
Regenerative medicine for the treatment of spinal cord injury: more than just promises? Regenerative medicine for the treatment of spinal cord injury: more than just promises?
skos:notation
RIV/68378041:_____/12:00383908!RIV13-AV0-68378041
n9:predkladatel
n10:ico%3A68378041
n3:aktivita
n11:Z n11:P n11:I
n3:aktivity
I, P(GAP304/11/0653), P(GAP304/11/0731), P(IAA500390902), Z(AV0Z50390703)
n3:cisloPeriodika
11
n3:dodaniDat
n17:2013
n3:domaciTvurceVysledku
n4:6738109 n4:3580318
n3:druhVysledku
n14:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
164596
n3:idVysledku
RIV/68378041:_____/12:00383908
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Spinal cord injury; cell therapies; stem cells
n3:klicoveSlovo
n6:cell%20therapies n6:Spinal%20cord%20injury n6:stem%20cells
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[115A732CC27E]
n3:nazevZdroje
Journal of Cellular and Molecular Medicine
n3:obor
n15:FH
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n19:GAP304%2F11%2F0653 n19:IAA500390902 n19:GAP304%2F11%2F0731
n3:rokUplatneniVysledku
n17:2012
n3:svazekPeriodika
16
n3:tvurceVysledku
Kubinová, Šárka Vanický, I. Mar, F. M. Syková, Eva Čížková, D. Sousa, M. M. Pêgo, A. P.
n3:wos
000310555200002
n3:zamer
n20:AV0Z50390703
s:issn
1582-1838
s:numberOfPages
18
n18:doi
10.1111/j.1582-4934.2012.01603.x