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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F11%3A00368381%21RIV12-AV0-68378041
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion. Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion.
dcterms:title
Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair
skos:prefLabel
Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair
skos:notation
RIV/68378041:_____/11:00368381!RIV12-AV0-68378041
n15:predkladatel
n18:ico%3A68378041
n4:aktivita
n7:Z n7:P
n4:aktivity
P(1M0538), P(GAP304/11/0731), P(GPP304/11/P633), P(IAA500390902), Z(AV0Z40500505), Z(AV0Z50390703)
n4:cisloPeriodika
4
n4:dodaniDat
n8:2012
n4:domaciTvurceVysledku
n11:8282900 n11:6738109 n11:3580318
n4:druhVysledku
n13:J
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
202078
n4:idVysledku
RIV/68378041:_____/11:00368381
n4:jazykVysledku
n17:eng
n4:klicovaSlova
2-hydroxyethyl methacrylate; scaffold; spinal cord repair
n4:klicoveSlovo
n9:scaffold n9:spinal%20cord%20repair n9:2-hydroxyethyl%20methacrylate
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[1E70CBBFA557]
n4:nazevZdroje
Journal of Biomedical Materials Research. Part A
n4:obor
n16:FH
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
6
n4:projekt
n10:1M0538 n10:GPP304%2F11%2FP633 n10:IAA500390902 n10:GAP304%2F11%2F0731
n4:rokUplatneniVysledku
n8:2011
n4:svazekPeriodika
99
n4:tvurceVysledku
Plichta, Zdeněk Hejčl, Aleš Kubinová, Šárka Syková, Eva Kotek, Jiří Horák, Daniel
n4:wos
000297019200012
n4:zamer
n20:AV0Z40500505 n20:AV0Z50390703
s:issn
1549-3296
s:numberOfPages
12
n19:doi
10.1002/jbm.a.33221