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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F11%3A00364583%21RIV12-AV0-68378041
rdf:type
skos:Concept n14:Vysledek
dcterms:description
In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway. In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway.
dcterms:title
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling
skos:prefLabel
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling
skos:notation
RIV/68378041:_____/11:00364583!RIV12-AV0-68378041
n14:predkladatel
n15:ico%3A68378041
n3:aktivita
n9:Z n9:S n9:P
n3:aktivity
P(GA304/07/0223), P(GA304/09/1579), S, Z(AV0Z50390512), Z(MSM0021620843)
n3:cisloPeriodika
18
n3:dodaniDat
n13:2012
n3:domaciTvurceVysledku
n6:4677811 n6:2937360 n6:6425755
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
226280
n3:idVysledku
RIV/68378041:_____/11:00364583
n3:jazykVysledku
n17:eng
n3:klicovaSlova
FGF signaling; Sprouty genes; Incisor
n3:klicoveSlovo
n7:Incisor n7:FGF%20signaling n7:Sprouty%20genes
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[CFF08D519841]
n3:nazevZdroje
Development
n3:obor
n20:EA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
14
n3:projekt
n18:GA304%2F07%2F0223 n18:GA304%2F09%2F1579
n3:rokUplatneniVysledku
n13:2011
n3:svazekPeriodika
138
n3:tvurceVysledku
Hovořáková, Mária Charles, C. Jheon, A. Viriot, L. Lyons, D. B. Lesot, H. Ahn, Y. Churavá, Svatava Biehs, B. Klein, O. D. Peterková, Renata Marangoni, P. Balooch, G. Krumlauf, R.
n3:wos
000294156000021
n3:zamer
n4:MSM0021620843 n4:AV0Z50390512
s:issn
0950-1991
s:numberOfPages
11
n16:doi
10.1242/dev.069195