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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F11%3A00360755%21RIV12-AV0-68378041
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Poly(N,N-diethylacrylamide) (PDEAAm) hydrogel scaffolds were prepared by radical copolymerization of N,Ndiethylacrylamide (DEAAm), N,N0-methylenebisacrylamide and methacrylic acid in the presence of (NH4)2SO4 or NaCl. The hydrogels were characterized by low-vacuum scanning electron microscopy in the water-swollen state, water and cyclohexane regain, and by mercury porosimetry. The pentapeptide, YIGSR-NH2, was immobilized on the hydrogel. Human embryonic stem cells (hESCs) were cultured with the hydrogels to test their biocompatibility. The results suggest that the PDEAAm hydrogel scaffolds are nontoxic and support hESC attachment and proliferation, and that interconnected pores of the scaffolds are important for hESC cultivation. Immobilization of YIGSR-NH2 pentapeptide on the PDEAAm surface improved both adhesion and growth of hESCs compared with the unmodified hydrogel. The YIGSRNH2- modified PDEAAm hydrogels may be a useful tool for tissue-engineering purposes. Poly(N,N-diethylacrylamide) (PDEAAm) hydrogel scaffolds were prepared by radical copolymerization of N,Ndiethylacrylamide (DEAAm), N,N0-methylenebisacrylamide and methacrylic acid in the presence of (NH4)2SO4 or NaCl. The hydrogels were characterized by low-vacuum scanning electron microscopy in the water-swollen state, water and cyclohexane regain, and by mercury porosimetry. The pentapeptide, YIGSR-NH2, was immobilized on the hydrogel. Human embryonic stem cells (hESCs) were cultured with the hydrogels to test their biocompatibility. The results suggest that the PDEAAm hydrogel scaffolds are nontoxic and support hESC attachment and proliferation, and that interconnected pores of the scaffolds are important for hESC cultivation. Immobilization of YIGSR-NH2 pentapeptide on the PDEAAm surface improved both adhesion and growth of hESCs compared with the unmodified hydrogel. The YIGSRNH2- modified PDEAAm hydrogels may be a useful tool for tissue-engineering purposes.
dcterms:title
Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering
skos:prefLabel
Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering Pentapeptide-modified poly(N,N-diethylacrylamide) hydrogel scaffolds for tissue engineering
skos:notation
RIV/68378041:_____/11:00360755!RIV12-AV0-68378041
n3:predkladatel
n4:ico%3A68378041
n5:aktivita
n12:P n12:Z
n5:aktivity
P(1M0538), P(GAP304/11/0731), P(LC06077), Z(AV0Z40500505), Z(AV0Z50390512), Z(AV0Z50390703), Z(MSM0021622430)
n5:cisloPeriodika
1
n5:dodaniDat
n13:2012
n5:domaciTvurceVysledku
n6:9569707 n6:8064296
n5:druhVysledku
n10:J
n5:duvernostUdaju
n7:S
n5:entitaPredkladatele
n15:predkladatel
n5:idSjednocenehoVysledku
219864
n5:idVysledku
RIV/68378041:_____/11:00360755
n5:jazykVysledku
n16:eng
n5:klicovaSlova
poly(N,N-diethylacrylamide); porosity; YIGSR peptide
n5:klicoveSlovo
n9:poly%28N n9:N-diethylacrylamide%29 n9:YIGSR%20peptide n9:porosity
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[492B1FB5CE9C]
n5:nazevZdroje
Journal of Biomedical Materials Research. Part B
n5:obor
n17:FH
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
8
n5:projekt
n20:GAP304%2F11%2F0731 n20:1M0538 n20:LC06077
n5:rokUplatneniVysledku
n13:2011
n5:svazekPeriodika
98B
n5:tvurceVysledku
Jaroš, J. Matulka, K. Horák, Daniel Hlídková, Helena Dvořák, Petr Lapčíková, Monika Beneš, Milan J. Hampl, Aleš
n5:wos
000291598900007
n5:zamer
n11:MSM0021622430 n11:AV0Z50390703 n11:AV0Z50390512 n11:AV0Z40500505
s:issn
1552-4973
s:numberOfPages
14
n14:doi
10.1002/jbm.b.31832