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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F11%3A00356231%21RIV11-MZP-68378041
rdf:type
n10:Vysledek skos:Concept
dcterms:description
We investigated associations between the levels of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes and pregnancy outcomes (intrauterine growth restriction, IUGR, low birth weight, LBW). Multivariate-adjusted logistic regression revealed that above-median 8-oxodG levels are the only factor significantly associated with the risk of IUGR (OR; 95% CI: 1.56; 1.07-2.37; p=0.022). Above-median levels of 8-oxodG were associated with an increased risk of LBW (OR; 95% CI: 1.88; 1.15- 3.06; p=0.011). Other variables associated with LBW included the newborn’s gender and gestational age, maternal smoking and haplotypes in the promoter region of the gene encoding mannose-binding lectin 2. We investigated associations between the levels of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes and pregnancy outcomes (intrauterine growth restriction, IUGR, low birth weight, LBW). Multivariate-adjusted logistic regression revealed that above-median 8-oxodG levels are the only factor significantly associated with the risk of IUGR (OR; 95% CI: 1.56; 1.07-2.37; p=0.022). Above-median levels of 8-oxodG were associated with an increased risk of LBW (OR; 95% CI: 1.88; 1.15- 3.06; p=0.011). Other variables associated with LBW included the newborn’s gender and gestational age, maternal smoking and haplotypes in the promoter region of the gene encoding mannose-binding lectin 2.
dcterms:title
Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic
skos:prefLabel
Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic
skos:notation
RIV/68378041:_____/11:00356231!RIV11-MZP-68378041
n10:predkladatel
n17:ico%3A68378041
n3:aktivita
n11:Z n11:P
n3:aktivity
P(SP/1B3/50/07), Z(AV0Z50390512)
n3:cisloPeriodika
2
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n8:7090889 n8:9462910 n8:2279312 n8:4713230 n8:8584273 n8:4106202 n8:9145516
n3:druhVysledku
n14:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
200983
n3:idVysledku
RIV/68378041:_____/11:00356231
n3:jazykVysledku
n16:eng
n3:klicovaSlova
air pollution; biomarkers; genetic polymorphisms
n3:klicoveSlovo
n13:genetic%20polymorphisms n13:biomarkers n13:air%20pollution
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A72E4077DB20]
n3:nazevZdroje
Environmental Health Perspectives
n3:obor
n19:DN
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n15:SP%2F1B3%2F50%2F07
n3:rokUplatneniVysledku
n9:2011
n3:svazekPeriodika
119
n3:tvurceVysledku
Špátová, Milada Chvátalová, Irena Dostál, Miroslav Tabashidze, Nana Rössner ml., Pavel Šrám, Radim Nováková, Zuzana
n3:wos
000286803400031
n3:zamer
n18:AV0Z50390512
s:issn
0091-6765
s:numberOfPages
7