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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F07%3A00342087%21RIV10-MZP-68378041
rdf:type
n6:Vysledek skos:Concept
dcterms:description
In the context of a molecular epidemiology study dealing with the effects of individual genetic susceptibility on childhood respiratory morbidity, DNA repair genotypes for XPD/ERCC2 gene in exon 6 (Arg156Arg) and exon 23 (Lys751Gln) have been analyzed in DNA samples isolated from fetal parts of placentas. The principal finding is that both genotypes are tightly linked. This strong linkage may have serious consequences for the interpretation of cancer susceptibility studies dealing with XPD6 and XPD23 genotypes. In the context of a molecular epidemiology study dealing with the effects of individual genetic susceptibility on childhood respiratory morbidity, DNA repair genotypes for XPD/ERCC2 gene in exon 6 (Arg156Arg) and exon 23 (Lys751Gln) have been analyzed in DNA samples isolated from fetal parts of placentas. The principal finding is that both genotypes are tightly linked. This strong linkage may have serious consequences for the interpretation of cancer susceptibility studies dealing with XPD6 and XPD23 genotypes.
dcterms:title
The DNA repair gene XPD/ERCC2 polymorphisms Arg156Arg (exon 6) and Lys751Gln (exon 23) are closely associated The DNA repair gene XPD/ERCC2 polymorphisms Arg156Arg (exon 6) and Lys751Gln (exon 23) are closely associated
skos:prefLabel
The DNA repair gene XPD/ERCC2 polymorphisms Arg156Arg (exon 6) and Lys751Gln (exon 23) are closely associated The DNA repair gene XPD/ERCC2 polymorphisms Arg156Arg (exon 6) and Lys751Gln (exon 23) are closely associated
skos:notation
RIV/68378041:_____/07:00342087!RIV10-MZP-68378041
n3:aktivita
n13:Z n13:R n13:P
n3:aktivity
P(SL/5/160/05), R, Z(AV0Z50390512)
n3:cisloPeriodika
-
n3:dodaniDat
n11:2010
n3:domaciTvurceVysledku
n5:7090889 n5:2279312 n5:9462910 n5:2944812
n3:druhVysledku
n16:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
417781
n3:idVysledku
RIV/68378041:_____/07:00342087
n3:jazykVysledku
n4:eng
n3:klicovaSlova
genetic polymorphism; DNA repair; cancer susceptibility
n3:klicoveSlovo
n7:genetic%20polymorphism n7:DNA%20repair n7:cancer%20susceptibility
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[3197C6B9482E]
n3:nazevZdroje
Toxicology Letters
n3:obor
n18:DN
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:projekt
n17:SL%2F5%2F160%2F05
n3:rokUplatneniVysledku
n11:2007
n3:svazekPeriodika
172
n3:tvurceVysledku
Topinka, Jan Greenfield, T. Šrám, Radim Yap, P. S. Herr, C. E. W. Hertz-Picciotto, I. Dostál, Miroslav Chvátalová, Irena
n3:zamer
n8:AV0Z50390512
s:issn
0378-4274
s:numberOfPages
5