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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F05%3A00026240%21RIV06-AV0-68378041
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Reelin is a secreted protein that regulates brain layer formation during embryonic development. Reelin binds several receptors, including two members of the low-density lipoprotein (LDL) receptor family, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR). Despite the high level of expression of Reelin and ApoER2 in the postnatal brain, their functions in the adult CNS remain elusive. Here, using electrophysiological, immunocytochemical, and biochemical approaches in cultured postnatal hippocampal neurons, we show that Reelin controls the change in subunit composition of somatic NMDA glutamate receptors (NMDARs) during maturation. Reelin is a secreted protein that regulates brain layer formation during embryonic development. Reelin binds several receptors, including two members of the low-density lipoprotein (LDL) receptor family, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR). Despite the high level of expression of Reelin and ApoER2 in the postnatal brain, their functions in the adult CNS remain elusive. Here, using electrophysiological, immunocytochemical, and biochemical approaches in cultured postnatal hippocampal neurons, we show that Reelin controls the change in subunit composition of somatic NMDA glutamate receptors (NMDARs) during maturation. V této publikaci dokládáme na buněčných primárních kulturách, velmi-nízce-densní Lipoproteinový receptor Reelin a Receptor 2 pro Apolipoprotein kontroluje podjednotkové složení N-methyl D-aspartátového receptoru (NMDA receptor) na buněčných tělech během maturace.
dcterms:title
Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro Reelin, velmi-nízce-densní Lipoproteinový receptor, a Receptor 2 pro Apolipoprotein kontroluje komposici somatického NMDA receptoru během dozrávání hippocampu In Vitro Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro
skos:prefLabel
Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro Reelin, velmi-nízce-densní Lipoproteinový receptor, a Receptor 2 pro Apolipoprotein kontroluje komposici somatického NMDA receptoru během dozrávání hippocampu In Vitro
skos:notation
RIV/68378041:_____/05:00026240!RIV06-AV0-68378041
n4:strany
6127;6136
n4:aktivita
n8:Z
n4:aktivity
Z(AV0Z5039906)
n4:cisloPeriodika
26
n4:dodaniDat
n7:2006
n4:domaciTvurceVysledku
n12:7203349 n12:1230883
n4:druhVysledku
n17:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
540417
n4:idVysledku
RIV/68378041:_____/05:00026240
n4:jazykVysledku
n15:eng
n4:klicovaSlova
hippocampus; maturation
n4:klicoveSlovo
n14:hippocampus n14:maturation
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[8C73A24DC753]
n4:nazevZdroje
Journal of Neuroscience
n4:obor
n9:FR
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
8
n4:rokUplatneniVysledku
n7:2005
n4:svazekPeriodika
25
n4:tvurceVysledku
Blahoš, Jaroslav Verrier, D. Manzoni, O. J. Korwek, K. M. Weeber, E. J. Sinagra, M. Chavis, P. Franková, Daniela
n4:zamer
n11:AV0Z5039906
s:issn
0270-6474
s:numberOfPages
10