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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F03%3A19043003%21RIV%2F2004%2FAV0%2FA19004%2FN
rdf:type
n3:Vysledek skos:Concept
dcterms:description
We proposed a hypothesis to explain the stimulation of apoptosis in the dental epithelium by integrating two concepts:(1) The regulation of epithelial bidding by positional information generated from interactions between growth-activating and growth-inhibiting signals, and (2) apoptosis stimulation by the failure of death-suppressing signals. During the budding of the dental epithelium, local excess in growth inhibitors (e.g.,Bmps)might lead to the epithelial cells' failure to receive adequate growth-activating (apoptosis-suppressing) signals. The resulting signal imbalance leads to cell suicide by apoptosis. Understanding of apoptosis regulation in the vestigial tooth primordia can help to elucidate the mechanism of their suppression during evolution and to identify factors essential for tooth survival. The latter knowledge will be important for developing a technology of tooth engineering. We proposed a hypothesis to explain the stimulation of apoptosis in the dental epithelium by integrating two concepts:(1) The regulation of epithelial bidding by positional information generated from interactions between growth-activating and growth-inhibiting signals, and (2) apoptosis stimulation by the failure of death-suppressing signals. During the budding of the dental epithelium, local excess in growth inhibitors (e.g.,Bmps)might lead to the epithelial cells' failure to receive adequate growth-activating (apoptosis-suppressing) signals. The resulting signal imbalance leads to cell suicide by apoptosis. Understanding of apoptosis regulation in the vestigial tooth primordia can help to elucidate the mechanism of their suppression during evolution and to identify factors essential for tooth survival. The latter knowledge will be important for developing a technology of tooth engineering.
dcterms:title
The Developing Mouse Dentition - a new tool for apoptosis study. The Developing Mouse Dentition - a new tool for apoptosis study.
skos:prefLabel
The Developing Mouse Dentition - a new tool for apoptosis study. The Developing Mouse Dentition - a new tool for apoptosis study.
skos:notation
RIV/68378041:_____/03:19043003!RIV/2004/AV0/A19004/N
n5:strany
453;466
n5:aktivita
n15:P n15:Z
n5:aktivity
P(GA304/02/0448), Z(AV0Z5039906)
n5:cisloPeriodika
N/A
n5:dodaniDat
n18:2004
n5:domaciTvurceVysledku
n8:4677811 n8:6093418
n5:druhVysledku
n13:J
n5:duvernostUdaju
n16:S
n5:entitaPredkladatele
n6:predkladatel
n5:idSjednocenehoVysledku
603441
n5:idVysledku
RIV/68378041:_____/03:19043003
n5:jazykVysledku
n9:eng
n5:klicovaSlova
apoptosis, tooth
n5:klicoveSlovo
n10:tooth n10:apoptosis
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[0082C13933BE]
n5:nazevZdroje
Annals of the New York Academy of Science
n5:obor
n17:EA
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
3
n5:pocetUcastnikuAkce
0
n5:pocetZahranicnichUcastnikuAkce
0
n5:projekt
n14:GA304%2F02%2F0448
n5:rokUplatneniVysledku
n18:2003
n5:svazekPeriodika
1010
n5:tvurceVysledku
Peterková, Renata Lesot, H. Peterka, Miroslav
n5:zamer
n7:AV0Z5039906
s:issn
0077-8923
s:numberOfPages
14