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Statements

Subject Item
n2:RIV%2F68378041%3A_____%2F02%3A19023087%21RIV%2F2003%2FGA0%2FA19003%2FN
rdf:type
skos:Concept n9:Vysledek
dcterms:description
The destruction of obsolete larval tissues at the onset of insect metamorphosis is a complex process triggered by the steroid hormone ecdysone. The reduced bristels on palpus (rbp) gene of the Broad-Complex (BR-C) locus plays a critical role in salivary gland (SG) degeneration. The BR-C locus encodes four major protein isoforms, including BR-C Z1, Z2, Z3, and Z4. We used transgenes expressing each of the four major BR-C isoform proteins and revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2,and Z4 first inhibited and then stimulated the process of SG degeneration. In contrast, BR-C Z3 exerted all time points an inhibition on SG degeneration. The destruction of obsolete larval tissues at the onset of insect metamorphosis is a complex process triggered by the steroid hormone ecdysone. The reduced bristels on palpus (rbp) gene of the Broad-Complex (BR-C) locus plays a critical role in salivary gland (SG) degeneration. The BR-C locus encodes four major protein isoforms, including BR-C Z1, Z2, Z3, and Z4. We used transgenes expressing each of the four major BR-C isoform proteins and revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2,and Z4 first inhibited and then stimulated the process of SG degeneration. In contrast, BR-C Z3 exerted all time points an inhibition on SG degeneration.
dcterms:title
Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors. Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors.
skos:prefLabel
Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors. Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors.
skos:notation
RIV/68378041:_____/02:19023087!RIV/2003/GA0/A19003/N
n3:strany
67;78
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA304/02/0342), Z(AV0Z5039906), Z(MSM 111100003)
n3:cisloPeriodika
N/A
n3:dodaniDat
n4:2003
n3:domaciTvurceVysledku
n17:2683350
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
666580
n3:idVysledku
RIV/68378041:_____/02:19023087
n3:jazykVysledku
n11:eng
n3:klicovaSlova
programmed cell death; BR-C transcription factors; drosophila
n3:klicoveSlovo
n5:programmed%20cell%20death n5:BR-C%20transcription%20factors n5:drosophila
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C4382E770188]
n3:nazevZdroje
Journal of Structural Biology
n3:obor
n14:EA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n10:GA304%2F02%2F0342
n3:rokUplatneniVysledku
n4:2002
n3:svazekPeriodika
140
n3:tvurceVysledku
Farkaš, R. Raška, Ivan Mechler, B. M. Kuchárová-Mahmood, S.
n3:zamer
n6:AV0Z5039906 n6:MSM%20111100003
s:issn
1047-8477
s:numberOfPages
12