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Statements

Subject Item
n2:RIV%2F68081766%3A_____%2F14%3A00433848%21RIV15-GA0-68081766
rdf:type
n5:Vysledek skos:Concept
dcterms:description
A number of Helicobacter species cause gastrointestinal or hepatic disease in humans, including H. pylori, gastric non-H. pylori helicobacters from animal origin and enterohepatic Helicobacter species. Little is known on the presence of Helicobacter species in great apes, our closest living relatives and potential reservoirs of microorganisms that might emerge in humans. The aim of the present study was to investigate the presence of gastric and enterohepatic Helicobacter species in African chimpanzees and gorillas. Fresh fecal samples were collected from wild endangered chimpanzees and critically endangered western lowland gorillas from different African National Parks, as well as wild-born captive animals from primate sanctuaries. Intact Helicobacter bacteria were demonstrated in feces by fluorescence in situ hybridization. Screening using a Helicobacter genus-specific PCR revealed the presence of Helicobacter DNA in the majority of animals in all groups. Cloning and sequencing of 16S rRNA gene fragments revealed a high homology to sequences from various zoonotic enterohepatic Helicobacter species, including H. cinaedi and H. canadensis. A number of gorillas and chimpanzees also tested positive using PCR assays designed to amplify part of the ureAB gene cluster and the hsp60 gene of gastric helicobacters. Phylogenetic analysis revealed the presence of a putative novel zoonotic gastric Helicobacter taxon/species. For this species, we propose the name Candidatus Helicobacter homininae’, pending isolation and further genetic characterization. The presence of several Helicobacter species not only implies a possible health threat for these endangered great apes, but also a possible zoonotic transmission of gastric and enterohepatic helicobacters from these primate reservoirs to humans. A number of Helicobacter species cause gastrointestinal or hepatic disease in humans, including H. pylori, gastric non-H. pylori helicobacters from animal origin and enterohepatic Helicobacter species. Little is known on the presence of Helicobacter species in great apes, our closest living relatives and potential reservoirs of microorganisms that might emerge in humans. The aim of the present study was to investigate the presence of gastric and enterohepatic Helicobacter species in African chimpanzees and gorillas. Fresh fecal samples were collected from wild endangered chimpanzees and critically endangered western lowland gorillas from different African National Parks, as well as wild-born captive animals from primate sanctuaries. Intact Helicobacter bacteria were demonstrated in feces by fluorescence in situ hybridization. Screening using a Helicobacter genus-specific PCR revealed the presence of Helicobacter DNA in the majority of animals in all groups. Cloning and sequencing of 16S rRNA gene fragments revealed a high homology to sequences from various zoonotic enterohepatic Helicobacter species, including H. cinaedi and H. canadensis. A number of gorillas and chimpanzees also tested positive using PCR assays designed to amplify part of the ureAB gene cluster and the hsp60 gene of gastric helicobacters. Phylogenetic analysis revealed the presence of a putative novel zoonotic gastric Helicobacter taxon/species. For this species, we propose the name Candidatus Helicobacter homininae’, pending isolation and further genetic characterization. The presence of several Helicobacter species not only implies a possible health threat for these endangered great apes, but also a possible zoonotic transmission of gastric and enterohepatic helicobacters from these primate reservoirs to humans.
dcterms:title
Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas
skos:prefLabel
Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas
skos:notation
RIV/68081766:_____/14:00433848!RIV15-GA0-68081766
n3:aktivita
n18:I n18:P
n3:aktivity
I, P(ED1.1.00/02.0068), P(GA206/09/0927)
n3:cisloPeriodika
1-2
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n12:1435787
n3:druhVysledku
n4:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
11931
n3:idVysledku
RIV/68081766:_____/14:00433848
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Enterohepatic Helicobacter species; Gastric Helicobacter species; Helicobacter cinaedi; Candidatus Helicobacter homininae; Chimpanzee; Gorilla
n3:klicoveSlovo
n8:Gastric%20Helicobacter%20species n8:Helicobacter%20cinaedi n8:Candidatus%20Helicobacter%20homininae n8:Enterohepatic%20Helicobacter%20species n8:Chimpanzee n8:Gorilla
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[3A3F11EE958F]
n3:nazevZdroje
Veterinary Microbiology
n3:obor
n14:EG
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
14
n3:projekt
n15:GA206%2F09%2F0927 n15:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
174
n3:tvurceVysledku
Petrželková, Klára Judita Sá, R. M. Kiang, J. Flahou, B. Todd, A. Haesebrouck, F. Smet, A. Ducatelle, R. Hashimoto, C. Pomajbíková, K. Modrý, D. Rossi, M. Mulama, M. Pasmans, F.
n3:wos
000345180500022
s:issn
0378-1135
s:numberOfPages
9
n13:doi
10.1016/j.vetmic.2014.08.032