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Statements

Subject Item
n2:RIV%2F68081766%3A_____%2F11%3A00347205%21RIV12-AV0-68081766
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed. The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed.
dcterms:title
Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations
skos:prefLabel
Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations
skos:notation
RIV/68081766:_____/11:00347205!RIV12-AV0-68081766
n11:predkladatel
n14:ico%3A68081766
n3:aktivita
n10:Z n10:P
n3:aktivity
P(GA206/08/0640), P(IAA600930608), Z(AV0Z60930519)
n3:cisloPeriodika
5
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n4:1659758 n4:5592364 n4:6833594
n3:druhVysledku
n18:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
201006
n3:idVysledku
RIV/68081766:_____/11:00347205
n3:jazykVysledku
n17:eng
n3:klicovaSlova
MHC; house mouse; selection; population structure; trans-species polymorphism
n3:klicoveSlovo
n6:selection n6:house%20mouse n6:MHC n6:population%20structure n6:trans-species%20polymorphism
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[39D289509B67]
n3:nazevZdroje
Heredity
n3:obor
n20:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n9:IAA600930608 n9:GA206%2F08%2F0640
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
106
n3:tvurceVysledku
Bryja, Josef Piálek, Jaroslav Baird, S. J. E. Goüy de Bellocq, J. Čížková, Dagmar
n3:wos
000289713700005
n3:zamer
n16:AV0Z60930519
s:issn
0018-067X
s:numberOfPages
14
n15:doi
10.1038/hdy.2010.112