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Statements

Subject Item
n2:RIV%2F68081766%3A_____%2F10%3A00342466%21RIV11-GA0-68081766
rdf:type
n5:Vysledek skos:Concept
dcterms:description
The phytohaemagglutinin (PHA) skin-swelling test is widely used in immunoecology and ecotoxicology to estimate cell-mediated immunity presumed to reveal T-cell mediated immunocompetence. To investigate the mechanism triggering this response we have compared in zebra finch (Taeniopygia guttata) the immune responses to two PHA isolectins (PHA-L and PHA-E) differing in their biological properties and one control protein. This is the first study to show the importance of erythroagglutination in the development of an inflammatory response to PHA-P. Our results indicate that the skin-swelling test using PHA-P reliably mirrors the individual general proinflammatory potential. The immunological background of the test is highly complex and the test results cannot be interpreted as measurements of the adaptive immunity or T-cell activity. This interpretational change importantly alters our view on the test results regarding the costs of the response or the evolutionary immunological adaptations. The phytohaemagglutinin (PHA) skin-swelling test is widely used in immunoecology and ecotoxicology to estimate cell-mediated immunity presumed to reveal T-cell mediated immunocompetence. To investigate the mechanism triggering this response we have compared in zebra finch (Taeniopygia guttata) the immune responses to two PHA isolectins (PHA-L and PHA-E) differing in their biological properties and one control protein. This is the first study to show the importance of erythroagglutination in the development of an inflammatory response to PHA-P. Our results indicate that the skin-swelling test using PHA-P reliably mirrors the individual general proinflammatory potential. The immunological background of the test is highly complex and the test results cannot be interpreted as measurements of the adaptive immunity or T-cell activity. This interpretational change importantly alters our view on the test results regarding the costs of the response or the evolutionary immunological adaptations.
dcterms:title
Functional analysis of the skin-swelling response to phytohaemagglutinin Functional analysis of the skin-swelling response to phytohaemagglutinin
skos:prefLabel
Functional analysis of the skin-swelling response to phytohaemagglutinin Functional analysis of the skin-swelling response to phytohaemagglutinin
skos:notation
RIV/68081766:_____/10:00342466!RIV11-GA0-68081766
n3:aktivita
n13:Z n13:P
n3:aktivity
P(GA206/08/0640), P(GA206/08/1281), P(LC06073), Z(AV0Z60930519), Z(MSM0021620828)
n3:cisloPeriodika
5
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n4:2571544 n4:1668722
n3:druhVysledku
n16:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
259932
n3:idVysledku
RIV/68081766:_____/10:00342466
n3:jazykVysledku
n15:eng
n3:klicovaSlova
avian innate and adaptive immunity; ecoimmunology; ecological immunology; ecotoxicology; inflammatory response; PHA-induced hypersensitivity; phytohaemagglutinin; T-cell-mediated immunocompetence
n3:klicoveSlovo
n8:avian%20innate%20and%20adaptive%20immunity n8:inflammatory%20response n8:PHA-induced%20hypersensitivity n8:ecoimmunology n8:ecological%20immunology n8:T-cell-mediated%20immunocompetence n8:phytohaemagglutinin n8:ecotoxicology
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2B5ABB5E70AE]
n3:nazevZdroje
Functional Ecology
n3:obor
n18:EG
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n6:GA206%2F08%2F1281 n6:GA206%2F08%2F0640 n6:LC06073
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
24
n3:tvurceVysledku
Bainová, H. Vinkler, Michal Albrecht, Tomáš
n3:wos
000281895800016
n3:zamer
n11:AV0Z60930519 n11:MSM0021620828
s:issn
0269-8463
s:numberOfPages
6