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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F14%3A00441300%21RIV15-GA0-68081707
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Background: The repair of spontaneous and induced DNA lesions is a multistep process. Depending on the type of injury, damaged DNA is recognized by many proteins specifically involved in distinct DNA repair pathways. Results: We analyzed the DNA-damage response after ultraviolet A (UVA) and. irradiation of mouse embryonic fibroblasts and focused on upstream binding factor 1 (UBF1), a key protein in the regulation of ribosomal gene transcription. We found that UBF1, but not nucleolar proteins RPA194, TCOF, or fibrillarin, was recruited to UVA-irradiated chromatin concurrently with an increase in heterochromatin protein 1 beta (HP1 beta) level. Moreover, Forster Resonance Energy Transfer (FRET) confirmed interaction between UBF1 and HP1 beta that was dependent on a functional chromo shadow domain of HP1 beta. Thus, overexpression of HP1 beta with a deleted chromo shadow domain had a dominant-negative effect on UBF1 recruitment to UVA-damaged chromatin. Background: The repair of spontaneous and induced DNA lesions is a multistep process. Depending on the type of injury, damaged DNA is recognized by many proteins specifically involved in distinct DNA repair pathways. Results: We analyzed the DNA-damage response after ultraviolet A (UVA) and. irradiation of mouse embryonic fibroblasts and focused on upstream binding factor 1 (UBF1), a key protein in the regulation of ribosomal gene transcription. We found that UBF1, but not nucleolar proteins RPA194, TCOF, or fibrillarin, was recruited to UVA-irradiated chromatin concurrently with an increase in heterochromatin protein 1 beta (HP1 beta) level. Moreover, Forster Resonance Energy Transfer (FRET) confirmed interaction between UBF1 and HP1 beta that was dependent on a functional chromo shadow domain of HP1 beta. Thus, overexpression of HP1 beta with a deleted chromo shadow domain had a dominant-negative effect on UBF1 recruitment to UVA-damaged chromatin.
dcterms:title
HP1 beta-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs HP1 beta-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs
skos:prefLabel
HP1 beta-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs HP1 beta-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs
skos:notation
RIV/68081707:_____/14:00441300!RIV15-GA0-68081707
n3:aktivita
n16:I n16:P
n3:aktivity
I, P(GA13-07822S), P(GAP302/10/1022), P(GBP302/12/G157)
n3:cisloPeriodika
DEC2014
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n10:4873130 n10:2682346 n10:9701125 n10:9180583 n10:2163608 n10:9620893 n10:4802675 n10:2231794
n3:druhVysledku
n18:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
19834
n3:idVysledku
RIV/68081707:_____/14:00441300
n3:jazykVysledku
n5:eng
n3:klicovaSlova
DNA-damage response; DNA repair; Irradiation
n3:klicoveSlovo
n11:Irradiation n11:DNA-damage%20response n11:DNA%20repair
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[DD3B04038BCD]
n3:nazevZdroje
Epigenetics & Chromatin
n3:obor
n12:BO
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
11
n3:projekt
n4:GA13-07822S n4:GAP302%2F10%2F1022 n4:GBP302%2F12%2FG157
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
7
n3:tvurceVysledku
Matula, Pa. Legartová, Soňa Fulneček, Jaroslav Suchánková, Jana Sehnalová, Petra Raška, I. Sorokin, D. V. Bártová, Eva Stixová, Lenka Kovařík, Aleš Hrušková, Tereza
n3:wos
000347931500001
s:issn
1756-8935
s:numberOfPages
17
n15:doi
10.1186/1756-8935-7-39