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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F14%3A00440095%21RIV15-GA0-68081707
rdf:type
n12:Vysledek skos:Concept
dcterms:description
The trinuclear platinum complexes (Triplatin NC-A [{Pt(NH3)(3)}(2)-mu-{trans-Pt(NH3)(2)(NH2(CH2)(6)NH2)(2)}](6+), and Triplatin NC [{trans-Pt(NH3)(2)(NH2(CH2)(6)NH3+)}(2)-mu-{trans-Pt(NH3)(2)(NH2(CH2)(6)NH2)(2)}](8+)) are biologically active agents that bind to DNA through noncovalent (hydrogen bonding, electrostatic) interactions. Herein, we show that TriplatinNC condenses DNAwith a much higher potency than conventional DNA condensing agents. Both complexes induce aggregation of small transfer RNA molecules, and TriplatinNC in particular completely inhibits DNA transcription at lower concentrations than naturally occurring spermine. Topoisomerase Imediated relaxation of supercoiled DNA was inhibited by TriplatinNC-A and TriplatinNC at concentrations which were 60 times and 250 times lower than that of spermine. The mechanisms for the biological activity of TriplatinNC-A and TriplatinNC may be associated with their ability to condense/aggregate nucleic acids with consequent inhibitory effects on crucial enzymatic activities. The trinuclear platinum complexes (Triplatin NC-A [{Pt(NH3)(3)}(2)-mu-{trans-Pt(NH3)(2)(NH2(CH2)(6)NH2)(2)}](6+), and Triplatin NC [{trans-Pt(NH3)(2)(NH2(CH2)(6)NH3+)}(2)-mu-{trans-Pt(NH3)(2)(NH2(CH2)(6)NH2)(2)}](8+)) are biologically active agents that bind to DNA through noncovalent (hydrogen bonding, electrostatic) interactions. Herein, we show that TriplatinNC condenses DNAwith a much higher potency than conventional DNA condensing agents. Both complexes induce aggregation of small transfer RNA molecules, and TriplatinNC in particular completely inhibits DNA transcription at lower concentrations than naturally occurring spermine. Topoisomerase Imediated relaxation of supercoiled DNA was inhibited by TriplatinNC-A and TriplatinNC at concentrations which were 60 times and 250 times lower than that of spermine. The mechanisms for the biological activity of TriplatinNC-A and TriplatinNC may be associated with their ability to condense/aggregate nucleic acids with consequent inhibitory effects on crucial enzymatic activities.
dcterms:title
Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity
skos:prefLabel
Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity
skos:notation
RIV/68081707:_____/14:00440095!RIV15-GA0-68081707
n3:aktivita
n17:I n17:P
n3:aktivity
I, P(GA13-08273S)
n3:cisloPeriodika
47
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n16:7988346 n16:9286667
n3:druhVysledku
n18:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
48472
n3:idVysledku
RIV/68081707:_____/14:00440095
n3:jazykVysledku
n14:eng
n3:klicovaSlova
DNA condensation; nucleic acids; platinum
n3:klicoveSlovo
n10:platinum n10:nucleic%20acids n10:DNA%20condensation
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[373B8F54E4EC]
n3:nazevZdroje
Angewandte Chemie - International Edition
n3:obor
n13:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n5:GA13-08273S
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
53
n3:tvurceVysledku
Farrell, N. P. Malina, Jaroslav Brabec, Viktor
n3:wos
000344793400023
s:issn
1433-7851
s:numberOfPages
5
n4:doi
10.1002/anie.201408012