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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F14%3A00435173%21RIV15-GA0-68081707
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Nuclear factor-kappa B (NF-kB) comprises a family of protein transcription factors that have a regulatory function in numerous cellular processes and are implicated in the cancer cell response to antineoplastic drugs, including cisplatin. We characterized the effects of DNA adducts of cisplatin and ineffective transplatin on the affinity of NF-kB proteins to their consensus DNA sequence (kB site). Although the kB site-NF-B protein interaction was significantly perturbed by DNA adducts of cisplatin, transplatin adducts were markedly less effective both in cell-free media and in cellulo using a decoy strategy derivatized-approach. Moreover, NF-B inhibitor JSH-23 [4-methyl-N-1-(3-phenylpropyl)benzene-1,2-diamine] augmented cisplatin cytotoxicity in ovarian cancer cells and the data showed strong synergy with JSH-23 for cisplatin. The distinctive structural features of DNA adducts of the two platinum complexes suggest a unique role for conformational distortions induced in DNA by the adducts of cisplatin with respect to inhibition of the binding of NF-kB to the platinated kB sites. Nuclear factor-kappa B (NF-kB) comprises a family of protein transcription factors that have a regulatory function in numerous cellular processes and are implicated in the cancer cell response to antineoplastic drugs, including cisplatin. We characterized the effects of DNA adducts of cisplatin and ineffective transplatin on the affinity of NF-kB proteins to their consensus DNA sequence (kB site). Although the kB site-NF-B protein interaction was significantly perturbed by DNA adducts of cisplatin, transplatin adducts were markedly less effective both in cell-free media and in cellulo using a decoy strategy derivatized-approach. Moreover, NF-B inhibitor JSH-23 [4-methyl-N-1-(3-phenylpropyl)benzene-1,2-diamine] augmented cisplatin cytotoxicity in ovarian cancer cells and the data showed strong synergy with JSH-23 for cisplatin. The distinctive structural features of DNA adducts of the two platinum complexes suggest a unique role for conformational distortions induced in DNA by the adducts of cisplatin with respect to inhibition of the binding of NF-kB to the platinated kB sites.
dcterms:title
Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer
skos:prefLabel
Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer
skos:notation
RIV/68081707:_____/14:00435173!RIV15-GA0-68081707
n3:aktivita
n18:I n18:P
n3:aktivity
I, P(GAP301/10/0598)
n3:cisloPeriodika
5
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n8:3900991 n8:1966154 n8:7988346 n8:4571932 n8:6345522
n3:druhVysledku
n17:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
11448
n3:idVysledku
RIV/68081707:_____/14:00435173
n3:jazykVysledku
n16:eng
n3:klicovaSlova
antitumor activity; cisplatin; DNA
n3:klicoveSlovo
n6:cisplatin n6:DNA n6:antitumor%20activity
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0E33D07B4E62]
n3:nazevZdroje
FEBS Journal
n3:obor
n15:BO
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
9
n3:projekt
n14:GAP301%2F10%2F0598
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
281
n3:tvurceVysledku
Brabec, Viktor Malinge, J. M. Thibault, T. Kašpárková, Jana Midoux, P. Kostrhunová, Hana Vojtíšková, Marie Štěpánková, Jana Muchová, T.
n3:wos
000332083600006
s:issn
1742-464X
s:numberOfPages
16
n12:doi
10.1111/febs.12711