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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F14%3A00435169%21RIV15-AV0-68081707
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development. Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development.
dcterms:title
Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
skos:prefLabel
Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
skos:notation
RIV/68081707:_____/14:00435169!RIV15-AV0-68081707
n3:aktivita
n15:I
n3:aktivity
I
n3:cisloPeriodika
April
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n4:1541145 n4:1791788 n4:2342154 n4:1075020 n4:9362746 n4:6752810 n4:1706063
n3:druhVysledku
n13:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
22281
n3:idVysledku
RIV/68081707:_____/14:00435169
n3:jazykVysledku
n11:eng
n3:klicovaSlova
NF-KAPPA-B; TRAIL-INDUCED APOPTOSIS; RECEPTOR-MEDIATED APOPTOSIS
n3:klicoveSlovo
n6:RECEPTOR-MEDIATED%20APOPTOSIS n6:NF-KAPPA-B n6:TRAIL-INDUCED%20APOPTOSIS
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4C8A905FCAB3]
n3:nazevZdroje
Mediators of Inflammation
n3:obor
n17:BO
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
2014
n3:tvurceVysledku
Tylichová, Zuzana Vaculová, Alena Šafaříková, Barbora Straková, Nicol Hofmanová, Jiřina Kozubík, Alois Skender, Belma
n3:wos
000335742300001
s:issn
0962-9351
s:numberOfPages
17
n9:doi
10.1155/2014/848632