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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F14%3A00431573%21RIV15-GA0-68081707
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid present in fish oil, may exert cytotoxic and/or cytostatic effects on colon cancer cells when applied individually or in combination with some anticancer drugs. Here we demonstrate a selective ability of subtoxic doses of DHA to enhance antiproliferative and apoptotic effects of clinically useful cytokine TRAIL (tumor necrosis factor-related apoptosis inducing ligand) in cancer but not normal human colon cells. DHA-mediated stimulation of TRAIL-induced apoptosis was associated with extensive engagement of mitochondrial pathway (Bax/Bak activation, drop of mitochondrial membrane potential, cytochrome c release), activation of endoplasmic reticulum stress response (CHOP upregulation, changes in PERK level), decrease of cellular inhibitor of apoptosis protein (XIAP, cIAP1) levels and significant changes in sphingolipid metabolism (intracellular levels of ceramides, hexosyl ceramides, sphingomyelines, sphingosines; HPLC/MS/MS). Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid present in fish oil, may exert cytotoxic and/or cytostatic effects on colon cancer cells when applied individually or in combination with some anticancer drugs. Here we demonstrate a selective ability of subtoxic doses of DHA to enhance antiproliferative and apoptotic effects of clinically useful cytokine TRAIL (tumor necrosis factor-related apoptosis inducing ligand) in cancer but not normal human colon cells. DHA-mediated stimulation of TRAIL-induced apoptosis was associated with extensive engagement of mitochondrial pathway (Bax/Bak activation, drop of mitochondrial membrane potential, cytochrome c release), activation of endoplasmic reticulum stress response (CHOP upregulation, changes in PERK level), decrease of cellular inhibitor of apoptosis protein (XIAP, cIAP1) levels and significant changes in sphingolipid metabolism (intracellular levels of ceramides, hexosyl ceramides, sphingomyelines, sphingosines; HPLC/MS/MS).
dcterms:title
DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism
skos:prefLabel
DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism
skos:notation
RIV/68081707:_____/14:00431573!RIV15-GA0-68081707
n3:aktivita
n6:P n6:I n6:Z
n3:aktivity
I, P(GA13-09766S), P(GAP301/11/1730), Z(MZE0002716202)
n3:cisloPeriodika
9
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n10:3140911 n10:1706063 n10:6752810 n10:2342154 n10:1075020
n3:druhVysledku
n19:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
11112
n3:idVysledku
RIV/68081707:_____/14:00431573
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Docosahexaenoic acid; TRAIL; Apoptosis
n3:klicoveSlovo
n5:Docosahexaenoic%20acid n5:Apoptosis n5:TRAIL
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[E52B6EB4425E]
n3:nazevZdroje
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
n3:obor
n4:BO
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:projekt
n12:GA13-09766S n12:GAP301%2F11%2F1730
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
1841
n3:tvurceVysledku
Moyer, M. P. Slavík, J. Vaculová, Alena Jelínková, Iva Skender, Belma Machala, M. Hofmanová, Jiřina Kozubík, Alois
n3:wos
000340019800012
n3:zamer
n15:MZE0002716202
s:issn
1388-1981
s:numberOfPages
10
n18:doi
10.1016/j.bbalip.2014.06.005