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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F14%3A00427968%21RIV15-GA0-68081707
rdf:type
n7:Vysledek skos:Concept
dcterms:description
here exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice. here exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice.
dcterms:title
Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice
skos:prefLabel
Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice
skos:notation
RIV/68081707:_____/14:00427968!RIV15-GA0-68081707
n4:aktivita
n12:P n12:I
n4:aktivity
I, P(GA305/08/0158), P(GAP303/11/0128)
n4:cisloPeriodika
1
n4:dodaniDat
n15:2015
n4:domaciTvurceVysledku
n10:5623596 n10:5087546 n10:6661971 n10:4311531
n4:druhVysledku
n14:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
1877
n4:idVysledku
RIV/68081707:_____/14:00427968
n4:jazykVysledku
n8:eng
n4:klicovaSlova
Ionizing radiation; Acute radiation disease; Survival
n4:klicoveSlovo
n5:Acute%20radiation%20disease n5:Ionizing%20radiation n5:Survival
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[A546E0542722]
n4:nazevZdroje
Radiation and Environmental Biophysics
n4:obor
n13:BO
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
5
n4:projekt
n11:GA305%2F08%2F0158 n11:GAP303%2F11%2F0128
n4:rokUplatneniVysledku
n15:2014
n4:svazekPeriodika
53
n4:tvurceVysledku
Pospíšil, Milan Dušek, L. Hoferová, Zuzana Komůrková, Denisa Hofer, Michal
n4:wos
000331977300018
s:issn
0301-634X
s:numberOfPages
5
n18:doi
10.1007/s00411-013-0500-y