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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F13%3A00392692%21RIV14-GA0-68081707
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Experimental and epidemiological evidence supports the idea that dietary fat and fiber influence colon carcinogenesis. Particularly, their components, n-3 polyunsaturated fatty acids (PUFAs) and butyrate, have been proven to exhibit beneficial effects on colon epithelial cell metabolism, signaling, and kinetics, thus preventing colon inflammation and cancer. Moreover, these effects may be strengthened by PUFA and butyrate combination. It appears that administration of these compounds might be a relatively nontoxic form of supportive therapy improving cancer treatment outcomes and slowing down or preventing recurrence of certain types of cancer. However, their efficient application has to be based on solid scientific evidence of their mechanisms of action from the molecular and cellular to the organismal level. Experimental and epidemiological evidence supports the idea that dietary fat and fiber influence colon carcinogenesis. Particularly, their components, n-3 polyunsaturated fatty acids (PUFAs) and butyrate, have been proven to exhibit beneficial effects on colon epithelial cell metabolism, signaling, and kinetics, thus preventing colon inflammation and cancer. Moreover, these effects may be strengthened by PUFA and butyrate combination. It appears that administration of these compounds might be a relatively nontoxic form of supportive therapy improving cancer treatment outcomes and slowing down or preventing recurrence of certain types of cancer. However, their efficient application has to be based on solid scientific evidence of their mechanisms of action from the molecular and cellular to the organismal level.
dcterms:title
Regulation of the Metabolism of Polyunsaturated Fatty Acids and Butyrate in Colon Cancer Cells Regulation of the Metabolism of Polyunsaturated Fatty Acids and Butyrate in Colon Cancer Cells
skos:prefLabel
Regulation of the Metabolism of Polyunsaturated Fatty Acids and Butyrate in Colon Cancer Cells Regulation of the Metabolism of Polyunsaturated Fatty Acids and Butyrate in Colon Cancer Cells
skos:notation
RIV/68081707:_____/13:00392692!RIV14-GA0-68081707
n5:predkladatel
n15:ico%3A68081707
n3:aktivita
n8:P n8:I n8:Z
n3:aktivity
I, P(GA301/07/1557), P(GA524/07/1178), P(GAP301/11/1730), Z(AV0Z50040702)
n3:cisloPeriodika
3
n3:dodaniDat
n18:2014
n3:domaciTvurceVysledku
n4:6752810 n4:1075020 n4:1706063
n3:druhVysledku
n7:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
102075
n3:idVysledku
RIV/68081707:_____/13:00392692
n3:jazykVysledku
n12:eng
n3:klicovaSlova
NF-KAPPA-B; HUMAN COLORECTAL-CANCER; INFLAMMATORY BOWEL DISEASES
n3:klicoveSlovo
n10:HUMAN%20COLORECTAL-CANCER n10:INFLAMMATORY%20BOWEL%20DISEASES n10:NF-KAPPA-B
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[9E395266ECEF]
n3:nazevZdroje
Current Pharmaceutical Biotechnology
n3:obor
n16:BO
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n14:GAP301%2F11%2F1730 n14:GA524%2F07%2F1178 n14:GA301%2F07%2F1557
n3:rokUplatneniVysledku
n18:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Kozubík, Alois Vaculová Hyršlová, Alena Hofmanová, Jiřina
n3:wos
000318162300004
n3:zamer
n13:AV0Z50040702
s:issn
1389-2010
s:numberOfPages
15