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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F13%3A00392682%21RIV14-GA0-68081707
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Cysteine oxidation and covalent modification of redox sensitive transcription factors including p53 are known, among others, as important events in cell response to oxidative stress. All p53 family proteins p53, p63 and p73 act as stress-responsive transcription factors. Oxidation of p53 central DNA binding domain destroys its structure and abolishes its sequence-specific binding by affecting zinc ion coordination at the protein-DNA interface. Proteins p63 and p73 can bind the same response elements as p53 but exhibit distinct functions. Moreover, all three proteins contain highly conserved cysteines in central DNA binding domain suitable for possible redox modulation. Cysteine oxidation and covalent modification of redox sensitive transcription factors including p53 are known, among others, as important events in cell response to oxidative stress. All p53 family proteins p53, p63 and p73 act as stress-responsive transcription factors. Oxidation of p53 central DNA binding domain destroys its structure and abolishes its sequence-specific binding by affecting zinc ion coordination at the protein-DNA interface. Proteins p63 and p73 can bind the same response elements as p53 but exhibit distinct functions. Moreover, all three proteins contain highly conserved cysteines in central DNA binding domain suitable for possible redox modulation.
dcterms:title
Redox state of p63 and p73 core domains regulates sequence-specific DNA binding Redox state of p63 and p73 core domains regulates sequence-specific DNA binding
skos:prefLabel
Redox state of p63 and p73 core domains regulates sequence-specific DNA binding Redox state of p63 and p73 core domains regulates sequence-specific DNA binding
skos:notation
RIV/68081707:_____/13:00392682!RIV14-GA0-68081707
n11:predkladatel
n12:ico%3A68081707
n5:aktivita
n7:I n7:P
n5:aktivity
I, P(GAP301/10/2370), P(GAP301/11/2076)
n5:cisloPeriodika
4
n5:dodaniDat
n18:2014
n5:domaciTvurceVysledku
n8:8970661 n8:1774352 n8:4171373 n8:8312095 n8:7209568
n5:druhVysledku
n6:J
n5:duvernostUdaju
n19:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
101830
n5:idVysledku
RIV/68081707:_____/13:00392682
n5:jazykVysledku
n15:eng
n5:klicovaSlova
TUMOR-SUPPRESSOR P53; RESPONSE ELEMENTS; SUPERCOILED DNA
n5:klicoveSlovo
n9:TUMOR-SUPPRESSOR%20P53 n9:SUPERCOILED%20DNA n9:RESPONSE%20ELEMENTS
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[E8DFB959BD3D]
n5:nazevZdroje
Biochemical and Biophysical Research Communications
n5:obor
n13:BO
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
5
n5:projekt
n10:GAP301%2F10%2F2370 n10:GAP301%2F11%2F2076
n5:rokUplatneniVysledku
n18:2013
n5:svazekPeriodika
433
n5:tvurceVysledku
Fojta, Miroslav Navrátilová, Lucie Brázdová, Marie Adámik, Matěj Tichý, Vlastimil
n5:wos
000318259100016
s:issn
0006-291X
s:numberOfPages
5
n4:doi
10.1016/j.bbrc.2013.02.097