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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F12%3A00440789%21RIV15-GA0-68081707
rdf:type
n17:Vysledek skos:Concept
dcterms:description
In our previous studies, IB-MECA, an adenosine A(3) receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after irradiation with sublethal doses of y-rays when the drug was given in a post-irradiation treatment regimen. This study was aimed at assessing the ability of IB-MECA to influence a 30-day survival of lethally irradiated mice. In a series of experiments, IB-MECA was administered following various lethal radiation doses in various numbers of drug doses and various administration routes. Though in some of these experiments a moderate increase in 30-day survival was observed in IB-MECA-treated mice, the differences in comparison with the controls were not significantly different. In our previous studies, IB-MECA, an adenosine A(3) receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after irradiation with sublethal doses of y-rays when the drug was given in a post-irradiation treatment regimen. This study was aimed at assessing the ability of IB-MECA to influence a 30-day survival of lethally irradiated mice. In a series of experiments, IB-MECA was administered following various lethal radiation doses in various numbers of drug doses and various administration routes. Though in some of these experiments a moderate increase in 30-day survival was observed in IB-MECA-treated mice, the differences in comparison with the controls were not significantly different.
dcterms:title
IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice
skos:prefLabel
IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice
skos:notation
RIV/68081707:_____/12:00440789!RIV15-GA0-68081707
n3:aktivita
n4:P n4:I
n3:aktivity
I, P(GA305/08/0158), P(GAP303/11/0128)
n3:cisloPeriodika
6
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n12:5623596 n12:6661971 n12:4311531 n12:5087546
n3:druhVysledku
n7:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
140184
n3:idVysledku
RIV/68081707:_____/12:00440789
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Mouse; IB-MECA; Adenosine A(3) receptor agonist
n3:klicoveSlovo
n8:IB-MECA n8:Adenosine%20A%283%29%20receptor%20agonist n8:Mouse
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[DF3098447BA2]
n3:nazevZdroje
Physiological Research
n3:obor
n5:BO
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n10:GA305%2F08%2F0158 n10:GAP303%2F11%2F0128
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
61
n3:tvurceVysledku
Komůrková, Denisa Pospíšil, Milan Dušek, L. Hoferová, Zuzana Hofer, Michal
n3:wos
000314138600011
s:issn
0862-8408
s:numberOfPages
6