This HTML5 document contains 52 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n8http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n9http://linked.opendata.cz/ontology/domain/vavai/
n7http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F68081707%3A_____%2F11%3A00441596%21RIV15-AV0-68081707/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n14http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n12http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F11%3A00441596%21RIV15-AV0-68081707
rdf:type
n9:Vysledek skos:Concept
dcterms:description
The purpose of the study was to investigate the effects of H(1)-antihistamines of the 1(st) generation (antazoline, bromadryl, brompheniramine, dithiaden, cyclizine, chlorcyclizine, chlorpheniramine, clemastine) and the 2(nd) generation (acrivastine, ketotifen, and loratadine) on the respiratory burst of phagocytes. Reactive oxygen species generation in neutrophils isolated from rat blood was measured using luminol-enhanced chemiluminescence. Changes in nitrite formation and iNOS protein expression by RAW 264.7 macrophages were analysed using Griess reaction and Western blotting. The antioxidative properties of drugs in cell-free systems were detected spectrophotometrically, luminometrically, fluorimetrically, and amperometrically. The majority of the H(1)-antihistamines tested (bromadryl, brompheniramine, chlorcyclizine, chlorpheniramine, clemastine, dithiaden, and ketotifen) exhibited a significant inhibitory effect on the chemiluminescence activity of phagocytes. The purpose of the study was to investigate the effects of H(1)-antihistamines of the 1(st) generation (antazoline, bromadryl, brompheniramine, dithiaden, cyclizine, chlorcyclizine, chlorpheniramine, clemastine) and the 2(nd) generation (acrivastine, ketotifen, and loratadine) on the respiratory burst of phagocytes. Reactive oxygen species generation in neutrophils isolated from rat blood was measured using luminol-enhanced chemiluminescence. Changes in nitrite formation and iNOS protein expression by RAW 264.7 macrophages were analysed using Griess reaction and Western blotting. The antioxidative properties of drugs in cell-free systems were detected spectrophotometrically, luminometrically, fluorimetrically, and amperometrically. The majority of the H(1)-antihistamines tested (bromadryl, brompheniramine, chlorcyclizine, chlorpheniramine, clemastine, dithiaden, and ketotifen) exhibited a significant inhibitory effect on the chemiluminescence activity of phagocytes.
dcterms:title
Modulation of metabolic activity of phagocytes by antihistamines. Modulation of metabolic activity of phagocytes by antihistamines.
skos:prefLabel
Modulation of metabolic activity of phagocytes by antihistamines. Modulation of metabolic activity of phagocytes by antihistamines.
skos:notation
RIV/68081707:_____/11:00441596!RIV15-AV0-68081707
n3:aktivita
n16:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n8:1758128 n8:3041581 n8:4837215 n8:3697940 n8:7038127 n8:6422268 n8:1332139 n8:7421575
n3:druhVysledku
n17:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
213434
n3:idVysledku
RIV/68081707:_____/11:00441596
n3:jazykVysledku
n4:eng
n3:klicovaSlova
antihistamines; nitric oxide; oxidative burst
n3:klicoveSlovo
n10:oxidative%20burst n10:nitric%20oxide n10:antihistamines
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[6D7A6F83E826]
n3:nazevZdroje
Interdisciplinary Toxicology
n3:obor
n15:BO
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
13
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
4
n3:tvurceVysledku
Jančinová, V. Ambrožová, Gabriela Číž, Milan Drábiková, K. Perečko, Tomáš Vašíček, Ondřej Moravcová, Jana Lojek, Antonín Kubala, Lukáš Pekarová, Michaela
s:issn
1337-6853
s:numberOfPages
7
n14:doi
10.2478/v10102-011-0004-z